Evidence map›Paper›PMID 30668190›Full record

ArticleLeukemia & lymphoma2019

DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin.

Jun Wang, David Van Den Berg, Amie E Hwang, Daniel Weisenberger, Timothy Triche, Bharat N Nathwani, David V Conti, Kim Siegmund, Thomas M Mack, Steve Horvath and 1 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia & lymphoma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Frailty and aging in cancer survivors.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jun Wanga Department of Preventive Medicine , University of Southern California , Los Angeles , CA , USA.
David Van Den Berga Department of Preventive Medicine , University of Southern California , Los Angeles , CA , USA.
Amie E Hwanga Department of Preventive Medicine , University of Southern California , Los Angeles , CA , USA.
Daniel Weisenbergerb Norris Comprehensive Cancer Center , University of Southern California , Los Angeles , CA , USA.
Timothy Trichec Department of Translational Genomics , University of Southern California , Los Angeles , CA , USA.
Bharat N Nathwanie Department of Pathology , City of Hope National Medical Center , Duarte , CA , USA.
David V Contia Department of Preventive Medicine , University of Southern California , Los Angeles , CA , USA.
Kim Siegmunda Department of Preventive Medicine , University of Southern California , Los Angeles , CA , USA.
Thomas M Macka Department of Preventive Medicine , University of Southern California , Los Angeles , CA , USA.
Steve Horvathg Department of Biostatistics , University of California at Los Angeles , Los Angeles , CA , USA.
Wendy Cozena Department of Preventive Medicine , University of Southern California , Los Angeles , CA , USA.

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
DNA methylation differences between identical twinsR01ES015150 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, THOMAS MCCULLOCH · 2006 to 2009
$3.1M
Cytokine Polymorphisms and Hodgkin Lymphoma RiskR03CA110836 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COZEN, WENDY · 2005 to 2006
$161k
NCI NIH HHS P30 CA014089NCI NIH HHS R03 CA110836NIEHS NIH HHS R01 ES015150
6 · The paper itself

Abstract

DNA methylation (DNAm) silences gene expression and may play a role in immune dysregulation that is characteristic of adolescent/young adult Hodgkin lymphoma (AYAHL). We used the Infinium HumanMethylation27 BeadChip to quantify DNAm in blood (

Indexed as

Cancer SurvivorsDNA MethylationAdolescentAdultAgedBiomarkers, TumorCpG IslandsEpigenesis, GeneticFemaleGenetic Association StudiesGenetic LociGenetic Predisposition to DiseaseHodgkin DiseaseHumansMaleMiddle AgedBiomarkers, TumorAYAbloodDNA methylationHodgkin lymphomasalivasurvivorstwins

Identifiers

PMID30668190
PMCPMC7781082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.