ReviewJournal of clinical periodontology2019
Barrier membranes: More than the barrier effect?
Review in Journal of clinical periodontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Premature Bone Resorption in Vertical Ridge Augmentation: A Systematic Review and Network Meta-Analysis of Randomised Clinical Trials.Clinical oral implants research · 2025Pooled it
- Effect of Different Membranes on Vertical Bone Regeneration: A Systematic Review and Network Meta-Analysis.BioMed research international · 2022Pooled it
- Block Versus Particulate Deproteinized Bovine Bone Mineral for Guided Bone Regeneration of Peri-Implant Dehiscence Defects: A 5-Year Randomized Controlled Trial.Clinical oral implants research · 2026Trial
- Early plaque formation on PTFE membranes with expanded or dense surface structures applied in the oral cavity of human volunteers.Clinical and experimental dental research · 2021Trial
- Effect of Membrane Perforations With and Without Collagen Membrane Coverage in Vertical Ridge Augmentation: An Experimental Pilot In Vivo Study.Clinical oral implants research · 2026Article
- Do collagen membranes with different thickness-related mechanical properties affect the outcomes of lateral bone augmentation? An immunohistochemical analysis.Clinical oral investigations · 2026Article
- Initial attachment, viability, proliferation, and migration of osteoblast-like SaOS-2 cells on two resorbable xenogeneic membranes for guided tissue regeneration: ab in vitro experimental study.Restorative dentistry & endodontics · 2026Article
- Tannic acid-assisted mechanical training transforms natural hydrogels into robust and bioactive membranes for guided bone regeneration.Materials today. Bio · 2026Article
- Biological and clinical responses to dense and expanded PTFE membranes in alveolar ridge preservation: A prospective non-randomized cohort study with ex vivo analyses.Clinical oral investigations · 2026Observational
- Do Collagenated Xenogenic Bone Substitutes Enhance Gingival Healing and Angiogenesis Through a Barrier Membrane? An In Vitro Study.Materials (Basel, Switzerland) · 2026Article
- Effect of L-shaped, loosely packed versus non-trimmed, compactly packed non-fixed collagenated bone blocks on the stability of augmented sites in chronic peri-implant dehiscence defects: a pre-clinicalJournal of periodontal & implant science · 2026Article
- Nanoscale Approaches to Oro-Dental Tissue Engineering: A Review of Strategies, Composites, and Translational Challenges.International journal of nanomedicine · 2026Review
- Vertical Ridge Augmentation in the Anterior Maxilla Using a Dual-Texture e-PTFE Membrane and Autogenous Bone: A 2- to 5-Year Retrospective Case-Series Study.Clinical oral implants research · 2025Article
- Fabrication and Characterization of Semi-Resorbable Bioactive Membrane Derived from Silk Fiber Sheet for Guided Bone Regeneration.Biomimetics (Basel, Switzerland) · 2025Article
- Bio-Membrane-Based Nanofiber Scaffolds: Targeted and Controlled Carriers for Drug Delivery-An Experimental In Vivo Study.Biomimetics (Basel, Switzerland) · 2025Article
- Does Early Re-Entry Surgery Following Simultaneous Guided Bone Regeneration Compromise the Dimension of Peri-Implant Tissues?Journal of clinical periodontology · 2025Article
- Biodegradable Zinc-Based Alloys for Guided Bone Regeneration Membranes: Feasibility, Current Status, and Future Prospects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Customized 3D-Printed Scaffolds for Alveolar Ridge Augmentation: A Scoping Review of Workflows, Technology, and Materials.Medicina (Kaunas, Lithuania) · 2025Article
- The eggshell membrane as a barrier membrane for guided bone regeneration.Regenerative medicine · 2025Article
- An axolotl limb regeneration-inspired strategy to enhance alveolar bone regeneration.Bioactive materials · 2025Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo review the knowledge on the mechanisms controlling membrane-host interactions in guided bone regeneration (GBR) and investigate the possible role of GBR membranes as bioactive compartments in addition to their established role as barriers. MATERIALS AND
methodsA narrative review was utilized based on in vitro, in vivo and available clinical studies on the cellular and molecular mechanisms underlying GBR and the possible bioactive role of membranes.
resultsEmerging data demonstrate that the membrane contributes bioactively to the regeneration of underlying defects. The cellular and molecular activities in the membrane are intimately linked to the promoted bone regeneration in the underlying defect. Along with the native bioactivity of GBR membranes, incorporating growth factors and cells in membranes or with graft materials may augment the regenerative processes in underlying defects.
conclusionIn parallel with its barrier function, the membrane plays an active role in hosting and modulating the molecular activities of the membrane-associated cells during GBR. The biological events in the membrane are linked to the bone regenerative and remodelling processes in the underlying defect. Furthermore, the bone-promoting environments in the two compartments can likely be boosted by strategies targeting both material aspects of the membrane and host tissue responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.