Evidence map›Paper›PMID 30667521›Full record

ArticleAlcoholism, clinical and experimental research2019

Gender Disparities in Alcohol Use Disorder Treatment Among Privately Insured Patients with Alcohol-Associated Cirrhosis.

Jessica L Mellinger, Anne Fernandez, Kerby Shedden, G Scott Winder, Robert J Fontana, Michael L Volk, Frederic C Blow, Anna S F Lok

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05375682 (Integrating Care for Patients With Alcohol Liver Disease and Mental Health and Alcohol Use Disorders), which is not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05375682 nacompletednot on this mapstarted 2024, after this paper: background citation

Integrating Care for Patients With Alcohol Liver Disease and Mental Health and Alcohol Use Disorders: A Pilot Study

TypeinterventionalSponsorUniversity of ManitobaRan2024 to 2026Enrolled30ConditionsAlcohol, LiverArmsIntegrated care program
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Sexual dimorphism in the liver.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  5. Article
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  10. Gender disparities in liver transplantation.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jessica L MellingerDivision of Gastroenterology and Hepatology , University of Michigan, Ann Arbor, Michigan.ORCID 0000-0001-7364-5035
Anne FernandezDepartment of Psychiatry , University of Michigan, Ann Arbor, Michigan.
Kerby SheddenDepartment of Statistics , University of Michigan, Ann Arbor, Michigan.
G Scott WinderDepartment of Psychiatry , University of Michigan, Ann Arbor, Michigan.
Robert J FontanaDivision of Gastroenterology and Hepatology , University of Michigan, Ann Arbor, Michigan.
Michael L VolkTransplantation Institute , Loma Linda University Health, Loma Linda, California.
Frederic C BlowDepartment of Psychiatry , University of Michigan, Ann Arbor, Michigan.
Anna S F LokDivision of Gastroenterology and Hepatology , University of Michigan, Ann Arbor, Michigan.
University of Michigan · USLoma Linda University · US

Funding

Improving Outcomes in Alcoholic Liver Disease: Integrating Behavioral Interventions into the Hepatology ClinicK23AA026333 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MELLINGER, JESSICA LEIGH · 2018 to 2022
$972k
Integrating Alcohol Screening, Brief Intervention, and Referral to Treatment into Presurgical CareK23AA023869 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FERNANDEZ, ANNE CHRISTIE · 2016 to 2020
$857k
American Association for the Study of Liver DiseasesNIAAA NIH HHS K23 AA023869NIAAA NIH HHS K23 AA026333
6 · The paper itself

Abstract

backgroundThe burden of alcohol-associated cirrhosis (AC) is high, and though alcohol cessation improves mortality, many patients fail to engage in alcohol use disorder (AUD) treatment and continue drinking. Our aim was to determine rates, predictors, and outcomes of AUD treatment utilization in AC patients with private insurance.

methodsWe collected data from persons with AC (diagnosed by ICD-9/ICD-10 codes), aged 18 to 64 years, enrolled in the Truven MarketScan Commercial Claims and Encounters database (2009 to 2016). We determined rates and predictors of substance abuse treatment visits as well as rates of alcohol relapse prevention medication prescriptions, weighted to the national employer-sponsored insured population. Effects of AUD treatment utilization on decompensation rates were calculated using proportional hazards regression with propensity score adjustment.

resultsA total of 66,053 AC patients were identified, 32% were female, and mean age at diagnosis was 54.5 years. About 72% had insurance coverage for substance abuse treatment. Overall, AUD treatment utilization rates were low, with only 10% receiving a face-to-face mental health or substance abuse visit and only 0.8% receiving a Food and Drug Administration (FDA)-approved relapse prevention medication within 1 year of index diagnosis. Women were less likely to receive a face-to-face visit (hazard ratio [HR] 0.84, p < 0.001) or an FDA-approved relapse prevention medication (0.89, p = 0.05) than men. AC patients who had a clinic visit for AUD treatment or used FDA-approved relapse medication showed decreased risk of decompensation at 1 year (HR 0.85, p < 0.001 for either).

conclusionsAUD treatment utilization is associated with lower decompensation rates among privately insured patients with AC. Women were less likely to utilize AUD treatment visits. Efforts to reduce gender-specific barriers to treatment are urgently needed to improve outcomes.

Indexed as

AdolescentAdultDrug UtilizationFemaleHumansInsurance, HealthLiver Cirrhosis, AlcoholicMaleMiddle AgedPatient Acceptance of Health CareSecondary PreventionSex FactorsYoung AdultAlcoholic CirrhosisFemaleSubstance Use TreatmentUtilization

Identifiers

PMID30667521
PMCPMC6379081
OpenAlexW2914775968

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.