Evidence map›Paper›PMID 30667177›Full record

ArticleJournal of biophotonics2019

Amphiphilic tetracationic porphyrins are exceptionally active antimicrobial photosensitizers: In vitro and in vivo studies with the free-base and Pd-chelate.

Weijun Xuan, Liyi Huang, Yuguang Wang, Xiaoqing Hu, Grzegorz Szewczyk, Ying-Ying Huang, Ahmed El-Hussein, Jerry C Bommer, Mark L Nelson, Tadeusz Sarna and 1 more

Abstract read
In one paragraph

Article in Journal of biophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Photodynamic inactivation of E. coli with cationic imidazolyl-porphyrin photosensitizers and their synergic combination with antimicrobial cinnamaldehyde.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Article
  2. Refining antimicrobial photodynamic therapy: effect of charge distribution and central metal ion in fluorinated porphyrins on effective control of planktonic and biofilm bacterial forms.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Article
  3. Review
  4. Review
  5. Photo-Inactivation ofAntibiotics (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weijun XuanDepartment of Otorhinolaryngology, Head and Neck Surgery, First Clinical Medical College and Hospital, Guangxi University of Chinese Medicine, Nanning, China.
Liyi HuangWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.
Yuguang WangWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.
Xiaoqing HuWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.
Grzegorz SzewczykDepartment of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Ying-Ying HuangWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.
Ahmed El-HusseinWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.
Jerry C BommerFrontier Scientific, Inc., Logan, Utah.
Mark L NelsonFrontier Scientific, Inc., Logan, Utah.
Tadeusz SarnaDepartment of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0001-6431-4605

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
Fulbright FoundationGuangxi Natural Science Foundation 2014GXNSFAA118162Guangxi Natural Science Foundation 2016GXNSFAA380312Guangxi Scientific and Technological Project 1355005-1-2National Natural Science Foundation of China 81260239National Natural Science Foundation of China 81260552National Natural Science Foundation of China 81373700National Natural Science Foundation of China 81472002National Natural Science Foundation of China 81774374National Natural Science Foundation of China 81860369NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700NIH HHS R01AI050875NIH HHS R21AI121700Poland National Science Center 2011/03/B/NZ1/00007Poland National Science Center 2013/08/W/NZ3/00700
6 · The paper itself

Abstract

Antimicrobial photodynamic inactivation (aPDI) employs the combination of nontoxic photosensitizing dyes and visible light to kill pathogenic microorganisms regardless of drug-resistance, and can be used to treat localized infections. A meso-substituted tetra-methylpyridinium porphyrin with one methyl group replaced by a C12 alkyl chain (FS111) and its Pd-derivative (FS111-Pd) were synthesized and tested as broad-spectrum antimicrobial photosensitizers when excited by blue light (5 or 10 J/cm

Indexed as

Hydrophobic and Hydrophilic InteractionsAnimalsAnti-Infective AgentsCandida albicansChelating AgentsEscherichia coliFemaleMicePalladiumPhotosensitizing AgentsPorphyrinsSinglet OxygenSuperoxidesAnti-Infective AgentsChelating AgentsPalladiumPhotosensitizing AgentsPorphyrinsSinglet OxygenSuperoxidesamphiphilic tetracationic porphyrinsantimicrobial photodynamic inactivationbioluminescence imagingbroad-spectrum activitypalladium-porphyrinuropathogenic Escherichia coli infection

Identifiers

PMID30667177
PMCPMC6646111

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.