ArticleeLife2019
The Crohn's disease polymorphism,
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- Bibliometric analysis of human microbiota-associated animal model (2005-2025).Frontiers in microbiology · 2026Pooled it
- Canonical and noncanonical autophagy in immunity.Immunity · 2026Review
- From Multi-Omics to Molecular Causality: A Five-Tier Evidence Framework for the Single-Bacterium-Metabolite Axis in IBD.Microorganisms · 2026Review
- Terminal Ileal Ulcers: Endoscopic Predictors for the Later Development of Crohn's Disease.Diagnostics (Basel, Switzerland) · 2026Article
- The AMP-antibiotic-microbiota triad in IBD: a mechanistic framework for dysregulated antimicrobial defense.Frontiers in immunology · 2026Review
- Gegen Qinlian Decoction, a classic traditional Chinese medicine formula: a potential therapeutic strategy for ulcerative colitis and colorectal cancer.Frontiers in pharmacology · 2026Review
- Mitophagy in inflammatory bowel disease: regulatory mechanisms and therapeutic potential.Frontiers in cell and developmental biology · 2026Review
- High throughput profiling of the B cell repertoire identifies systematic changes in the repertoire of individuals with Crohn's disease.Frontiers in immunology · 2026Article
- Mental health and gut-brain crosstalk: implications for depression and Alzheimer's disease.Neuroscience applied · 2026Review
- Infection strategies ofGut microbes reports · 2026Review
- Selenium: A Key Element in Inflammatory Bowel Disease.Antioxidants (Basel, Switzerland) · 2025Review
- Small Intestine on a Chip Demonstrates Physiologic Mucus Secretion in the Presence of Lacticaseibacillus rhamnosus Biofilm.Biotechnology and bioengineering · 2025Article
- Article
- TSP50 deficiency in neural stem cells aggravates colitis in mice by altering intestinal microbiome.NPJ biofilms and microbiomes · 2025Article
- Gut microbiota modulate intestinal inflammation by endoplasmic reticulum stress-autophagy-cell death signaling axis.Journal of animal science and biotechnology · 2025Review
- Gut Microbiota Modulation in IBD: From the Old Paradigm to Revolutionary Tools.International journal of molecular sciences · 2025Review
- Impact of Microbiota Diversity on Inflammatory Bowel Disease.Microorganisms · 2025Article
- Inhibition of Atg7 in intestinal epithelial cells drives resistance against Citrobacter rodentium.Cell death & disease · 2025Article
- Immunohistochemistry Analysis in Inflammatory Bowel Disease-Should We Bring to Light Interleukin-10?Biomedicines · 2025Article
- Mechanism of cell death and its application in the repair of inflammatory bowel disease by mesenchymal stem cells.Frontiers in immunology · 2025Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
Sydney LavoieDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.ORCID 0000-0003-2890-3634
Kara L ConwayGastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, United States.
Kara G LassenBroad Institute of Harvard and MIT, Cambridge, United States.ORCID 0000-0001-7023-461X
Humberto B JijonGastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, United States.
Hui PanJoslin Diabetes Center, Boston, United States.
Eunyoung ChunDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Monia MichaudDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Jessica K LangDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Carey Ann Gallini ComeauDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Jonathan M DreyfussJoslin Diabetes Center, Boston, United States.
Jonathan N GlickmanDepartment of Pathology, Harvard Medical School, Boston, United States.
Hera VlamakisBroad Institute of Harvard and MIT, Cambridge, United States.
Ashwin AnanthakrishnanGastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, United States.
Aleksander Kostic *Joslin Diabetes Center, Boston, United States.
Wendy S Garrett *Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.ORCID 0000-0002-5092-0150
Ramnik J Xavier *Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, United States.
Boston University · USBroad Institute · USMassachusetts General Hospital · USJoslin Diabetes Center · US
Funding
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MA comprehensive platform for novel therapy development from the microbiomeR24DK110499 · NIDDK · BROAD INSTITUTE, INC. · PI HUTTENHOWER, CURTIS · 2017 to 2021
$7.7MGut microbiota and inflammatory monocytes in colorectal cancerR01CA154426 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI GARRETT, WENDY S. · 2011 to 2025
$5.2MATG16L1 T300A: genetics to biologyR01DK097485 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI XAVIER, RAMNIK J · 2013 to 2021
$4.1MAutophagy genes and the microbiome in Crohn's DiseaseR01DK092405 · NIDDK · BROAD INSTITUTE, INC. · PI XAVIER, RAMNIK J · 2012 to 2014
$2.0MThe Effect of Autophagy on the Generation and Function of Gut Regulatory T CellsF31DK105653 · NIDDK · HARVARD MEDICAL SCHOOL · PI LAVOIE, SYDNEY · 2015 to 2017
$102kNCI NIH HHS R01 CA154426NIDDK NIH HHS F31 DK105653NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK092405NIDDK NIH HHS R01 DK097485NIDDK NIH HHS R24 DK110499NIH HHS CA154426NIH HHS DK092405NIH HHS DK097485NIH HHS DK105653NIH HHS DK110499Richard and Susan Smith Family Foundation Smith Family Foundation Award for Excellence in Biomedical Research
Abstract
Inflammatory bowel disease (IBD) is driven by dysfunction between host genetics, the microbiota, and immune system. Knowledge gaps remain regarding how IBD genetic risk loci drive gut microbiota changes. The Crohn's disease risk allele
Indexed as
Gastrointestinal MicrobiomeAllelesAnimalsAutophagy-Related ProteinsBacteroidesCrohn DiseaseDysbiosisFecal Microbiota TransplantationFecesGene Knock-In TechniquesGenotypeHumansImmune SystemMicePolymorphism, GeneticRiskAtg16l1 protein, mouseAutophagy-Related ProteinsATG16L1T300ABacteroidesBacteroides ovatusCrohn's Diseasegutimmunologyinfectious diseaseinflammationmicrobiologymouseT cell
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.