ArticleeLife2019
Gut microbiota density influences host physiology and is shaped by host and microbial factors.
Abstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signal.Genome biology · 2022Pooled it
- Genomic analysis ofMicrobiology spectrum · 2026Article
- Beyond the Lungs: ICU Oral Care and Gut Resilience-A Hypothesis-Generating Narrative Review.Microorganisms · 2026Review
- Anatomical, physiological, and luminal adaptations occurring in an ileoanal pouch: opportunities for improving outcomes.Inflammatory bowel diseases · 2026Review
- Maternal and infant gut microbiome.iMeta · 2026Review
- Rare Taxa and Stochastic Drift Drive the Microbiome Assembly of the Invasive Pest Drosophila suzukii, While Host Filtering Structures the Grape Sour Rot Community.Microbial ecology · 2026Article
- Integration of donor microbiota following FMT correlates with anti-PD-1 response in melanoma.Nature communications · 2026Article
- Saffron Alters Microbial Amino Acid Metabolism and Neurotransmitter Production in a Defined Gut Consortium.Food science & nutrition · 2026Article
- Article
- Late-onset sepsis treatment in very preterm infants alters longitudinal microbiome trajectory with lower abundance ofGut microbes · 2025Article
- Leveraging strain competition to address antimicrobial resistance with microbiota therapies.Gut microbes · 2025Review
- Precision microbiota therapy for IBD: premise and promise.Gut microbes · 2025Review
- Absolute quantification of prokaryotes in the microbiome by 16S rRNA qPCR or ddPCR.Nature protocols · 2025Review
- Review
- Cystic fibrosis and inflammatory bowel disease: parallels in gut physiology and microbiota.Journal of bacteriology · 2025Review
- Uncertainty Modeling Outperforms Machine Learning for Microbiome Data Analysis.bioRxiv : the preprint server for biology · 2025Article
- The total gut mucosal and fecal bacterial load increases in successful treatment of inflammatory bowel disease with infliximab.Microbiology spectrum · 2025Article
- Persistent delay in maturation of the developing gut microbiota in infants with cystic fibrosis.mBio · 2025Article
- Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation.Nature immunology · 2025Article
- Encounter rates and engagement times limit the transmission of conjugative plasmids.PLoS genetics · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
74 authors.
Eduardo J ContijochPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.ORCID 0000-0002-2873-6808
Graham J BrittonPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Chao YangPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Ilaria MognoPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Zhihua LiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Ruby NgPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Sean R LlewellynPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Sheela HiraZoo Knoxville, Knoxville, United States.
Crystal JohnsonCenter for Comparative Medicine and Surgery, Icahn School of Medicine at Mount Sinai, New York, United States.
Keren M RabinowitzDivision of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel.
Revital BarkanDivision of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel.
Iris DotanDivision of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel.
Robert P HirtenThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Shih-Chen FuIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Yuying LuoThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Nancy YangThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Tramy LuongIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Philippe R LabriasIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Sergio LiraPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Inga PeterIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Ari GrinspanThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Jose C ClementePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.ORCID 0000-0002-3970-9856
Roman KosoyIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Seunghee Kim-SchulzeDivision of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Xiaochen QinPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Anabella CastilloThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Amanda HurleyIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Ashish AtrejaThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Jason RogersThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Farah FasihuddinThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Merjona SaliajThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Amy NolanThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Pamela Reyes-MercedesThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Carina RodriguezThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Sarah AlyThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Kenneth Santa-CruzThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Lauren PetersDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
Mayte Suárez-FariñasIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Ruiqi HuangIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Ke HaoIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Jun ZhuIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Bin ZhangIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Bojan LosicIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Haritz IrizarIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Won-Min SongIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Antonio Di NarzoIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.ORCID 0000-0002-4033-5038
Wenhui WangIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Benjamin L CohenThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Christopher DiMaioThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
David GreenwaldThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Steven ItzkowitzThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Aimee LucasThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
James MarionThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Elana MaserThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Ryan UngaroThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Steven NaymagonThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Joshua NovakThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Brijen ShahThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Thomas UllmanThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Peter RubinThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
James GeorgeThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Peter LegnaniThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Shannon E TelescoResearch and Development, Janssen Pharmaceuticals, Pennsylvania, United States.
Joshua R FriedmanResearch and Development, Janssen Pharmaceuticals, Pennsylvania, United States.
Carrie BrodmerkelResearch and Development, Janssen Pharmaceuticals, Pennsylvania, United States.
Scott PlevyResearch and Development, Janssen Pharmaceuticals, Pennsylvania, United States.
Judy H ChoThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.ORCID 0000-0002-7959-0466
Jean-Frederic ColombelThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Eric E SchadtSema4, Stamford, United States.
Carmen ArgmannIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Marla DubinskyPediatric Gastroenterology and Hepatology, Department of Pediatrics, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai, New York, United States.
Andrew KasarskisIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, United States.
Bruce SandsThe Dr. Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, United States.
Jeremiah J FaithPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.ORCID 0000-0002-2691-4500
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MProject 3 - Ex vivo immune profiling of dengue viruses and vaccinesU19AI118610 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KASARSKIS, ANDREW · 2015 to 2021
$46.6MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MMOUNT SINAI MEDICAL SCIENTIST TRAINING PROGRAMT32GM007280 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BARON, MARGARET H · 1985 to 2021
$22.8MMechanisms associated with flares and remission in colitisR01DK110352 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2017 to 2025
$5.1MMolecular pathogenesis of intestinal serrated polypsR01CA161373 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2011 to 2020
$3.7MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MThe relationship between host diet, the gut microbiota, and host transcriptionR01GM108505 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAITH, JEREMIAH JAMES · 2014 to 2017
$1.7MImproving Fecal Microbiota Transplantation Engraftment and EfficacyF31DK112679 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CONTIJOCH, EDUARDO JOSE · 2017 to 2019
$141kNCI NIH HHS P30 CA016087NCI NIH HHS R01 CA161373NIAID NIH HHS U19 AI118610NIDDK NIH HHS DK112679NIDDK NIH HHS F31 DK112679NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R01 DK110352NIGMS NIH HHS GM007280NIGMS NIH HHS GM108505NIGMS NIH HHS R01 GM108505NIGMS NIH HHS T32 GM007280NIH HHS S10 OD018522
Abstract
To identify factors that regulate gut microbiota density and the impact of varied microbiota density on health, we assayed this fundamental ecosystem property in fecal samples across mammals, human disease, and therapeutic interventions. Physiologic features of the host (carrying capacity) and the fitness of the gut microbiota shape microbiota density. Therapeutic manipulation of microbiota density in mice altered host metabolic and immune homeostasis. In humans, gut microbiota density was reduced in Crohn's disease, ulcerative colitis, and ileal pouch-anal anastomosis. The gut microbiota in recurrent Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
Indexed as
Fecal Microbiota TransplantationGastrointestinal MicrobiomeAdiposityAdultAgedAged, 80 and overAnimalsClostridioides difficileClostridium InfectionsCrohn DiseaseFemaleHomeostasisHumansIleumImmune SystemInflammatory Bowel DiseasesRNA, Ribosomal, 16Sfecal microbiota transplantationgut microbiomehumanhuman biologyinfectious diseaseinflammatory bowel diseasemedicinemicrobiologymicrobiota densitymouse
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