ArticleEmerging infectious diseases2019
Echinococcus multilocularis Infection, Southern Ontario, Canada.
Article in Emerging infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century.Infection · 2019Pooled it
- Prevalence and distribution ofOne health (Amsterdam, Netherlands) · 2026Article
- Localization of the Complement C1q-Binding Site onTropical medicine and infectious disease · 2026Article
- Safeguarding Canadian pets and humans: A call to strengthen regulations for importing companion animals.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2026Review
- Enhancing the structural stability of P29-targeted monoclonal antibodies via β-hydroxybutyrylation modification improves their therapeutic performance in alveolar echinococcosis.Frontiers in cellular and infection microbiology · 2025Article
- Human echinococcosis incidence in Canada: A retrospective descriptive study using administrative hospital and ambulatory visit data, 2000-2020.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2024Article
- Plasma Circulating Cell-Free DNA Facilitated the Detection of an Alveolar Echinococcosis Patient Initially Misdiagnosed as Cystic Echinococcosis: A Case Report.Tropical medicine and infectious disease · 2024Article
- Review
- mmu-miR-374b-5p modulated inflammatory factors via downregulation of C/EBP β/NF-κB signaling in Kupffer cells during Echinococcus multilocularis infection.Parasites & vectors · 2024Article
- Prevalence and geographic distribution of Echinococcus genus in wild canids in southern Québec, Canada.PloS one · 2024Article
- Alveolar Echinococcus in a 70-year-old man in Ontario.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024Article
- A Canadian children's hospital's experience with cystic echinococcosis over 30 years: A case series.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024Article
- Unraveling the Consequences of Oxygen Imbalance on Early Embryo Development: Exploring Mitigation Strategies.Animals : an open access journal from MDPI · 2023Review
- NOVEL REPORT OF THE EUROPEAN VARIANT OF ECHINOCOCCUS MULTILOCULARIS IN COYOTES (CANIS LATRANS) IN NEW YORK STATE.The Journal of parasitology · 2023Article
- A survey of gastrointestinal parasites in dogs illegally entering the UK (2015-2017).Veterinary record open · 2023Article
- Response of wild rodents to red fox feces: implication for the echinococcus infection.The Journal of veterinary medical science · 2023Article
- It's a small world for parasites: evidence supporting the North American invasion of EuropeanProceedings. Biological sciences · 2023Article
- Host spatiotemporal overlap in a park with high endemicity ofFrontiers in parasitology · 2023Article
- Canine Alveolar Echinococcosis: An Emerging and Costly Introduced Problem in North America.Transboundary and emerging diseases · 2023Article
- Age-dependent relationships among diet, body condition, and Echinococcus multilocularis infection in urban coyotes.PloS one · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Alveolar echinococcosis, the disease caused by infection with the intermediate stage of the Echinococcus multilocularis tapeworm, is typically fatal in humans and dogs when left untreated. Since 2012, alveolar echinococcosis has been diagnosed in 5 dogs, 3 lemurs, and 1 chipmunk in southern Ontario, Canada, a region previously considered free of these tapeworms. Because of human and animal health concerns, we estimated prevalence of infection in wild canids across southern Ontario. During 2015-2017, we collected fecal samples from 460 wild canids (416 coyotes, 44 foxes) during postmortem examination and analyzed them by using a semiautomated magnetic capture probe DNA extraction and real-time PCR method for E. multilocularis DNA. Surprisingly, 23% (95% CI 20%-27%) of samples tested positive. By using a spatial scan test, we identified an infection cluster (relative risk 2.26; p = 0.002) in the western-central region of the province. The cluster encompasses areas of dense human population, suggesting zoonotic transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.