Evidence map›Paper›PMID 30666921›Full record

ReviewPharmaceutical nanotechnology2019

Drug Combinations in Breast Cancer Therapy.

Funmilola A Fisusi, Emmanuel O Akala

3 registry-linked trialsAbstract readReview
In one paragraph

Review in Pharmaceutical nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 201 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05576545 nacompletednot on this mapstarted 2020, after this paper: background citation

Develop and Evaluate the Effectiveness of a Self-Care Smartphone Application on the Self-Efficacy, and Resilience Among Newly Diagnosed Breast Cancer Patients Undergoing Treatment

TypeinterventionalSponsorKaohsiung Medical University Chung-Ho Memorial HospitalRan2020 to 2022Enrolled73ConditionsBreast Cancer, Breast Neoplasm, Breast Malignant Tumor, ResilienceArmsThe Breast Cancer Self-Care App
NCT05663723 nacompletednot on this mapstarted 2023, after this paper: background citation

Photobiomodulation for Prevention of Chemotherapy-induced Peripheral Neuropathy in Women With Breast Cancer

TypeinterventionalSponsorErica Alves Nogueira FabroRan2023 to 2024Enrolled186ConditionsPeripheral Nervous System Diseases AND Breast NeoplasmsArmsIntervention group with the IV and V LED board, Intervention group with the IV, V and Violet LED board, Control group with LED board without emitting light
NCT05882578 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Exercise Oncology Intervention in Fitness Capacity and Body Composition in Breast Cancer Survivals

TypeinterventionalSponsorTigers Running ClubRan2023 to 2023Enrolled74ConditionsBreast Cancer, Cancer SurvivorsArmsOncological physical exercise intervention, Active Physical Activities intervention
3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Pooled it
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  8. Cephaeline promotes ferroptosis in breast cancer via p53/SLC7A11/GPX4 axis.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
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  9. Review
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  18. Review
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  20. The smoothing factor in breast intensity-modulated radiotherapy: dosimetric impact and a predictive model of plan acceptability.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026
    Article

141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Funmilola A FisusiCenter for Drug Research and Development, Department of Pharmaceutical Sciences, College of Pharmacy, Howard University, Washington, DC, United States.
Emmanuel O AkalaCenter for Drug Research and Development, Department of Pharmaceutical Sciences, College of Pharmacy, Howard University, Washington, DC, United States.

Funding

EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAM: REN*: PROSTATE BREAST CANCERC06RR020608 · NCRR · HOWARD UNIVERSITY · PI ADDERLEY-KELLY, BEATRICE · 2004 to 2004
$3.5M
RENOVATION THIRD FLOOR CHAUNCEY I. COOPER HALL-PHARMACYC06RR014469 · NCRR · HOWARD UNIVERSITY · PI LECCA, PEDRO J · 2000 to 2000
$1.0M
Novel Nanotechnology Platform for Breast Cancer TreatmentSC1CA199810 · NCI · HOWARD UNIVERSITY · PI AKALA, EMMANUEL O · 2015 to 2018
$969k
NCI NIH HHS SC1 CA199810NCRR NIH HHS C06 RR014469NCRR NIH HHS C06 RR020608
6 · The paper itself

Abstract

Breast cancer therapy involves a multidisciplinary approach comprising surgery, radiotherapy, neoadjuvant and adjuvant therapy. Effective therapy of breast cancer requires maximum therapeutic efficacy, with minimal undesirable effects to ensure a good quality of life for patients. The carefully selected combination of therapeutic interventions provides patients with the opportunity to derive maximum benefit from therapy while minimizing or eliminating recurrence, resistance and toxic effects, as well as ensuring that patients have a good quality of life. This review discusses therapeutic options for breast cancer treatments and various combinations that had been previously exploited. The review will also give an insight into the potential application of the nanotechnology platform for codelivery of therapeutics in breast cancer therapy.

Indexed as

Antineoplastic AgentsBreast NeoplasmsDrug Delivery SystemsDrug ResistanceDrug Therapy, CombinationFemaleHumansMolecular Targeted TherapyNanoparticlesNeoadjuvant TherapyNeoplasm Recurrence, LocalQuality of LifeAntineoplastic AgentsBreast cancerchemotherapycombination therapyearly breast cancermetastatic breast cancernanotechnologyradiotherapysurgery.

Identifiers

PMID30666921
PMCPMC6691849

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.