ArticleJournal of Zhejiang University. Science. B
Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets.
Article in Journal of Zhejiang University. Science. B. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Evaluation of probiotic supplementation to enhance growth, immune response, intestinal function, and survival in extensively raised neonatal alpacas in the Peruvian Central-southern Andes.Veterinary and animal science · 2026Article
- Article
- Early-life intervention withFrontiers in microbiology · 2026Article
- The potential probiotic role of Lacticaseibacillus rhamnosus on growth performance, gut health, and immune responses of weaned pigs.Journal of animal science · 2025Article
- Probiotic Lactobacillus rhamnosus GG improves insulin sensitivity and offspring survival via modulation of gut microbiota and serum metabolite in a sow model.Journal of animal science and biotechnology · 2024Article
- Research progress in isolation and identification of rumen probiotics.Frontiers in cellular and infection microbiology · 2024Review
- Effects of dietary Lactobacillus rhamnosus GG supplementation on the production performance, egg quality, eggshell ultrastructure, and lipid metabolism of late-phase laying hens.BMC veterinary research · 2023Article
- Probing the functional and therapeutic properties of postbiotics in relation to their industrial application.Food science & nutrition · 2023Review
- Mechanisms and applications of probiotics in prevention and treatment of swine diseases.Porcine health management · 2023Review
- Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy.Molecules (Basel, Switzerland) · 2023Review
- In Vitro and In Vivo Evaluation of Lacticaseibacillus rhamnosus GG and Bifidobacterium lactis Bb12 Against Avian Pathogenic Escherichia coli and Identification of Novel Probiotic-Derived Bioactive Peptides.Probiotics and antimicrobial proteins · 2022Article
- Molecular characterization of gut microbiome in weaning pigs supplemented with multi-strain probiotics using metagenomic, culturomic, and metabolomic approaches.Animal microbiome · 2022Article
- Stability and volatility shape the gut bacteriome and Kazachstania slooffiae dynamics in preweaning, nursery and adult pigs.Scientific reports · 2022Article
- Lactobacillus rhamnosus GG ameliorates DON-induced intestinal damage depending on the enrichment of beneficial bacteria in weaned piglets.Journal of animal science and biotechnology · 2022Article
- Effects of a multi-strain probiotic on growth, health, and fecal bacterial flora of neonatal dairy calves.Animal bioscience · 2022Article
- Effects of Maternal Factors and Postpartum Environment on Early Colonization of Intestinal Microbiota in Piglets.Frontiers in veterinary science · 2022Article
- A meta-analysis ofFrontiers in veterinary science · 2022Article
- Effects of blended microbial feed additives on performance, meat quality, gut microbiota and metabolism of broilers.Frontiers in nutrition · 2022Article
- Effects of dietary inactivated probiotics on growth performance and immune responses of weaned pigs.Journal of animal science and technology · 2021Article
- Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the effects of Lactobacillus rhamnosus GG (ATCC 53103) on intestinal barrier function in pre-weaning piglets under normal conditions, twenty-four newborn littermate piglets were randomly divided into two groups. Piglets in the control group were orally administered with 2 mL 0.1 g/mL sterilized skim milk while the treatment group was administered the same volume of sterilized skim milk with the addition of viable L. rhamnosus at the 1st, 3rd, and 5th days after birth. The feeding trial was conducted for 25 d. Results showed that piglets in the L. rhamnosus group exhibited increased weaning weight and average daily weight gain, whereas diarrhea incidence was decreased. The bacterial abundance and composition of cecal contents, especially Firmicutes, Bacteroidetes, and Fusobacteria, were altered by probiotic treatment. In addition, L. rhamnosus increased the jejunal permeability and promoted the immunologic barrier through regulating antimicrobial peptides, cytokines, and chemokines via Toll-like receptors. Our findings indicate that oral administration of L. rhamnosus GG to newborn piglets is beneficial for intestinal health of pre-weaning piglets by improving the biological, physical, and immunologic barriers of intestinal mucosa.
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