Evidence map›Paper›PMID 30666821›Full record

ArticleStem cells translational medicine2019

Chondroitin Sulfate Glycosaminoglycan Scaffolds for Cell and Recombinant Protein-Based Bone Regeneration.

Seth Andrews, Albert Cheng, Hazel Stevens, Meghan T Logun, Robin Webb, Erin Jordan, Boao Xia, Lohitash Karumbaiah, Robert E Guldberg, Steven Stice

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Advances in Growth Factor Delivery for Bone Tissue Engineering.International journal of molecular sciences · 2021
    Review
  10. Review
  11. Review
  12. Cell Scaffolds for Bone Tissue Engineering.Bioengineering (Basel, Switzerland) · 2020
    Article
  13. Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: Making the right choices.Journal of controlled release : official journal of the Controlled Release Society · 2019
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Seth AndrewsRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.ORCID 0000-0003-2867-8000
Albert ChengGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Hazel StevensGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Meghan T LogunRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.
Robin WebbRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.
Erin JordanRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.
Boao XiaGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Lohitash KarumbaiahRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.
Robert E GuldbergGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Steven SticeRegenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.
University of Georgia · USGeorgia Institute of Technology · US

Funding

Creating Endogenous Stem Cell Niches to Promote Functional Brain Repair Post-TBIR01NS099596 · NINDS · UNIVERSITY OF GEORGIA · PI KARUMBAIAH, LOHITASH · 2017 to 2021
$1.6M
6 · The paper itself

Abstract

Bone morphogenetic protein 2 (BMP-2)-loaded collagen sponges remain the clinical standard for treatment of large bone defects when there is insufficient autograft, despite associated complications. Recent efforts to negate comorbidities have included biomaterials and gene therapy approaches to extend the duration of BMP-2 release and activity. In this study, we compared the collagen sponge clinical standard to chondroitin sulfate glycosaminoglycan (CS-GAG) scaffolds as a delivery vehicle for recombinant human BMP-2 (rhBMP-2) and rhBMP-2 expression via human BMP-2 gene inserted into mesenchymal stem cells (BMP-2 MSC). We demonstrated extended release of rhBMP-2 from CS-GAG scaffolds compared to their collagen sponge counterparts, and further extended release from CS-GAG gels seeded with BMP-2 MSC. When used to treat a challenging critically sized femoral defect model in rats, both rhBMP-2 and BMP-2 MSC in CS-GAG induced comparable bone formation to the rhBMP-2 in collagen sponge, as measured by bone volume, strength, and stiffness. We conclude that CS-GAG scaffolds are a promising delivery vehicle for controlling the release of rhBMP-2 and to mediate the repair of critically sized segmental bone defects. Stem Cells Translational Medicine 2019;8:575-585.

Indexed as

AnimalsBone DiseasesBone Morphogenetic Protein 2Bone RegenerationChondroitin SulfatesCollagenFemaleHumansHydrogelsMesenchymal Stem CellsMesenchymal Stem Cell TransplantationNanofibersRatsRats, NudeRecombinant ProteinsTissue ScaffoldsBone Morphogenetic Protein 2chondroitin sulfate glycosaminoglycanChondroitin SulfatesCollagenHydrogelsrecombinant human bone morphogenetic protein-2Recombinant ProteinsTransforming Growth Factor betaBone morphogenetic protein-2Chondroitin sulfate glycosaminoglycanGenetic therapyMesenchymal stromal cellsOsteogenesis

Identifiers

PMID30666821
PMCPMC6525555
OpenAlexW2914704638

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.