Evidence map›Paper›PMID 30666804›Full record

ArticleJournal of tissue engineering and regenerative medicine2019

In vitro cellular testing of strontium/calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration.

Uresha Patel, Laura Macri-Pellizzeri, Kazi M Zakir Hossain, Brigitte E Scammell, David M Grant, Colin A Scotchford, Alex C Hannon, Andrew R Kennedy, Emma R Barney, Ifty Ahmed and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of tissue engineering and regenerative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Recent developments in strontium-based biocomposites for bone regeneration.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Uresha PatelFaculty of Engineering, University of Nottingham, Nottingham, UK.
Laura Macri-PellizzeriFaculty of Engineering, University of Nottingham, Nottingham, UK.ORCID 0000-0002-0457-1869
Kazi M Zakir HossainFaculty of Engineering, University of Nottingham, Nottingham, UK.
Brigitte E ScammellOrthopaedics and Trauma Group, Division of Rheumatology, Orthopaedics, and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK.
David M GrantFaculty of Engineering, University of Nottingham, Nottingham, UK.
Colin A ScotchfordFaculty of Engineering, University of Nottingham, Nottingham, UK.
Alex C HannonISIS Facility, Rutherford Appleton Laboratory, Chilton, Didcot, UK.
Andrew R KennedyFaculty of Science and Technology, Lancaster University, Lancaster, UK.
Emma R BarneyFaculty of Engineering, University of Nottingham, Nottingham, UK.
Ifty AhmedFaculty of Engineering, University of Nottingham, Nottingham, UK.
Virginie SottileWolfson STEM Centre, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0002-6064-5738
University of Nottingham · GBLancaster University · GBRutherford Appleton Laboratory · GB

Funding

Department of Health II-C3-0714-20001Science and Technology Facilities Council ST/L502583/1
6 · The paper itself

Abstract

Phosphate-based glasses (PBGs) are ideal materials for regenerative medicine strategies because their composition, degradation rates, and ion release profiles can easily be controlled. Strontium has previously been found to simultaneously affect bone resorption and deposition. Therefore, by combining the inherent properties of resorbable PBG and therapeutic activity of strontium, these glasses could be used as a delivery device of therapeutic factors for the treatment of orthopaedic diseases such as osteoporosis. This study shows the cytocompatibility and osteogenic potential of PBGs where CaO is gradually replaced by SrO in the near invert glass system 40P

Indexed as

MicrospheresAlkaline PhosphataseBone RegenerationCalciumCell LineCell ProliferationDNAGlassHumansMesenchymal Stem CellsPhosphatesStrontiumAlkaline PhosphataseCalciumDNAPhosphatesStrontiumbone regenerationcalcium phosphate glassstem cellsstrontium

Identifiers

PMID30666804
PMCPMC6492078
OpenAlexW2914133323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.