ArticleHuman brain mapping2019
Cortical and structural-connectivity damage correlated with impaired syntactic processing in aphasia.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- The Neurofunctional Correlates of Morphosyntactic and Thematic Impairments in Aphasia: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Task-Free Functional Language Networks: Reproducibility and Clinical Application.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Pooled it
- Distinct Patterns of Syntactic Errors Doubly Dissociate in Chronic Poststroke Aphasia.Journal of cognitive neuroscience · 2026Article
- From structure to sequence: A multinomial processing tree model of syntactic encoding.Psychonomic bulletin & review · 2026Article
- Characterizing Verb Argument Structure in Aphasia Using Dependency Parsers.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Frontal Vulnerability versus Temporal Resilience within the Core Language Network: Neuro-compensatory Mechanisms Underline Differential Language Aging Trajectories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Language biomarker screening using AI: a transdiagnostic approach to the brain.Scientific reports · 2026Article
- Simultaneous tDCS-rTMS stimulation to regulate the language network and improve language ability in Landau-Kleffner syndrome.Epilepsia open · 2025Article
- Audiovisual Synchrony in Left-hemisphere Brain-lesioned Individuals with Aphasia.Journal of cognitive neuroscience · 2025Article
- Fixel-Based White Matter Correlates of Sentence Comprehension in Post-Stroke Aphasia.Brain sciences · 2025Article
- Influence of lexical and phonological variables on the production of verb tense in agrammatism.Aphasiology · 2025Article
- Distinct neural correlates of morphosyntactic and thematic comprehension processes in aphasia.Brain communications · 2025Article
- Neural Predictors for the Generalization of Semantic and Phonological Treatment to Discourse Performance in Chronic Post-Stroke Aphasia.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Benchmarking machine learning models in lesion-symptom mapping for predicting language outcomes in stroke survivors.Frontiers in neuroimaging · 2025Article
- Temporoparietal brain structures support sentence processing across the adult lifespan.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Network-based statistics distinguish anomic and Broca's aphasia.Brain structure & function · 2024Article
- Structural Disconnections Caused by White Matter Hyperintensities in Post-Stroke Spatial Neglect.Human brain mapping · 2024Article
- Lesion-symptom Mapping of Acceptability Judgments in Chronic Poststroke Aphasia Reveals the Neurobiological Underpinnings of Receptive Syntax.Journal of cognitive neuroscience · 2024Article
- Neural mechanisms of sentence production: a volumetric study of primary progressive aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Effects of Transcranial Direct Current Stimulation on Graph Naming Function and Brain Connectivity in Postinfarction Aphasia Patients: An fMRI Study.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Agrammatism in aphasia is not a homogeneous syndrome, but a characterization of a nonuniform set of language behaviors in which grammatical markers and complex syntactic structures are omitted, simplified, or misinterpreted. In a sample of 71 left-hemisphere stroke survivors, syntactic processing was quantified with the Northwestern Assessment of Verbs and Sentences (NAVS). Classification analyses were used to assess the relation between NAVS performance and morphosyntactically reduced speech in picture descriptions. Voxel-based and connectivity-based lesion-symptom mapping were applied to investigate neural correlates of impaired syntactic processing. Despite a nonrandom correspondence between NAVS performance and morphosyntactic production deficits, there was variation in individual patterns of syntactic processing. Morphosyntactically reduced production was predicted by lesions to left-hemisphere inferior frontal cortex. Impaired verb argument structure production was predicted by damage to left-hemisphere posterior superior temporal and angular gyrus, as well as to a ventral pathway between temporal and frontal cortex. Damage to this pathway was also predictive of impaired sentence comprehension and production, particularly of noncanonical sentences. Although agrammatic speech production is primarily predicted by lesions to inferior frontal cortex, other aspects of syntactic processing rely rather on regional integrity in temporoparietal cortex and the ventral stream.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.