ArticleHuman brain mapping2019
Generalizing age effects on brain structure and cognition: A two-study comparison approach.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Multimodal investigation of the association between shift work and the brain in a population-based sample of older adults.Scientific reports · 2022Trial
- Characterizing progressive cortical thinning in multiple system atrophy: a longitudinal MRI study.NPJ Parkinson's disease · 2026Article
- Differential predictability of cognitive profiles from brain structure in older males and females.GeroScience · 2024Article
- Prediction of cognitive performance differences in older age from multimodal neuroimaging data.GeroScience · 2024Article
- Translating phenotypic prediction models from big to small anatomical MRI data using meta-matching.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Abnormal Brain Structure Is Associated with Social and Communication Deficits in Children with Autism Spectrum Disorder: A Voxel-Based Morphometry Analysis.Brain sciences · 2023Article
- Musicianship-Related Structural and Functional Cortical Features Are Preserved in Elderly Musicians.Frontiers in aging neuroscience · 2022Article
- In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- When your brain looks older than expected: combined lifestyle risk and BrainAGE.Brain structure & function · 2021Article
- Generalizing Longitudinal Age Effects on Brain Structure - A Two-Study Comparison Approach.Frontiers in human neuroscience · 2021Article
- Hippocampus co-atrophy pattern in dementia deviates from covariance patterns across the lifespan.Brain : a journal of neurology · 2020Article
- Individual Differences in Interoceptive Accuracy Are Correlated With Salience Network Connectivity in Older Adults.Frontiers in aging neuroscience · 2020Article
- Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study.Frontiers in psychiatry · 2020Article
- Generalizing age effects on brain structure and cognition: A two-study comparison approach.Human brain mapping · 2019Article
- Lagged Coupled Changes Between White Matter Microstructure and Processing Speed in Healthy Aging: A Longitudinal Investigation.Frontiers in aging neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Normal aging is accompanied by an interindividually variable decline in cognitive abilities and brain structure. This variability, in combination with methodical differences and differences in sample characteristics across studies, pose a major challenge for generalizability of results from different studies. Therefore, the current study aimed at cross-validating age-related differences in cognitive abilities and brain structure (measured using cortical thickness [CT]) in two large independent samples, each consisting of 228 healthy older adults aged between 65 and 85 years: the Longitudinal Healthy Aging Brain (LHAB) database (University of Zurich, Switzerland) and the 1000BRAINS (Research Centre Jülich, Germany). Participants from LHAB showed significantly higher education, physical well-being, and cognitive abilities (processing speed, concept shifting, reasoning, semantic verbal fluency, and vocabulary). In contrast, CT values were larger for participants of 1000BRAINS. Though, both samples showed highly similar age-related differences in both, cognitive abilities and CT. These effects were in accordance with functional aging theories, for example, posterior to anterior shift in aging as was shown for the default mode network. Thus, the current two-study approach provides evidence that independently on heterogeneous metrics of brain structure or cognition across studies, age-related effects on cognitive ability and brain structure can be generalized over different samples, assuming the same methodology is used.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.