Evidence map›Paper›PMID 30666738›Full record

ArticleProtein science : a publication of the Protein Society2019

Characterization and structure determination of prolyl-tRNA synthetase from Pseudomonas aeruginosa and development as a screening platform.

Noah Pena, David M Dranow, Yanmei Hu, Yaritza Escamilla, James M Bullard

Open access · bronzeAbstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Architecture ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Adaptive evolution: Eukaryotic enzyme's specificity shift to a bacterial substrate.Protein science : a publication of the Protein Society · 2024
    Article
  6. Article
  7. Two Forms of Tyrosyl-tRNA Synthetase fromSLAS discovery : advancing life sciences R & D · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Noah PenaThe University of Texas - RGV, Edinburg, Texas 78541.
David M DranowSeattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.
Yanmei HuThe University of Texas - RGV, Edinburg, Texas 78541.
Yaritza EscamillaThe University of Texas - RGV, Edinburg, Texas 78541.
James M BullardThe University of Texas - RGV, Edinburg, Texas 78541.
The University of Texas Rio Grande Valley · USBeryllium (United States) · US

Funding

University of Chicago Initiative for Maximizing Student Development (IMSD) - Renewal 01R25GM109439 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHWARTZ, NANCY B · 2014 to 2023
$5.7M
UTPA RISE Undergraduate Training ProgramR25GM100866 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI DEARTH, ROBERT KEITH, PARSONS, JASON · 2012 to 2016
$1.8M
Construction of a Protein Synthesis System from Pseudomonas aeruginosa for Screening for Antibacterial CandidatesSC3GM098173 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI BULLARD, JAMES M · 2012 to 2019
$861k
NIAID NIH HHS Contract No.: HHSN272201700059CNIAID NIH HHS HHSN272201700059CNIGMS NIH HHS 1SC3GM098173NIGMS NIH HHS R25 GM100866NIGMS NIH HHS R25 GM109439NIGMS NIH HHS SC3 GM098173NIH HHS 1R25GM100866
6 · The paper itself

Abstract

Pseudomonas aeruginosa is an opportunistic multi-drug resistant pathogen implicated as a causative agent in nosocomial and community acquired bacterial infections. The gene encoding prolyl-tRNA synthetase (ProRS) from P. aeruginosa was overexpressed in Escherichia coli and the resulting protein was characterized. ProRS was kinetically evaluated and the K

Indexed as

Amino Acyl-tRNA SynthetasesBacterial ProteinsCrystallography, X-RayHumansMicrobial Sensitivity TestsModels, MolecularProtein ConformationPseudomonas aeruginosaPseudomonas InfectionsAmino Acyl-tRNA SynthetasesBacterial Proteinsprolyl T RNA synthetaseaminoacyl-tRNA synthetaseantibioticsdrug discoveryprotein synthesisproyl-tRNA synthetasePseudomonas aeruginosa

Identifiers

PMID30666738
PMCPMC6423717
OpenAlexW2911793801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.