Evidence map›Paper›PMID 30666612›Full record

ReviewPain and therapy2019

Chronic Pain in the Elderly with Cognitive Decline: A Narrative Review.

Luca Cravello, Simona Di Santo, Giustino Varrassi, Dario Benincasa, Paolo Marchettini, Marina de Tommaso, Jacob Shofany, Francesca Assogna, Daniele Perotta, Katie Palmer and 3 more

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Pain and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07768033 (THE EFFECT OF CHAIR-ASSISTED YOGA PRACTICE ON SLEEP QUALITY AND PAIN LEVELS IN ELDERLY INDIVIDUALS LIVING IN NURSING HOMES), which is not on this map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07768033 nacompletednot on this mapstarted 2026, after this paper: background citation

The effect of chair-assisted yoga practice on sleep quality and pain levels in elderly individuals living in nursing homes

TypeinterventionalSponsorRüveyda BerkRan2026 to 2026Enrolled36ConditionsSleep Quality, PainArmsChair-Supported Yoga
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Experimentally evoked pain in Alzheimer's disease.Journal of the American Association of Nurse Practitioners · 2021
    Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Chronic Pain and Cognitive Dysfunction: Clinical Implement, Mechanism, and Therapeutic Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Dyadic Comparison of Pain and Stress in Alzheimer's Disease and Caregivers.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2025
    Article
  17. Article
  18. Role of NLRP3 Inflammasome in Chronic Pain and Alzheimer's Disease-A Review.Journal of biochemical and molecular toxicology · 2025
    Review
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

Luca CravelloCentro Regionale Alzheimer ASST Rhodense, Passirana di Rho Hospital, Milan, Italy. lcravello@asst-rhodense.it.
Simona Di SantoIRCCS Fondazione Santa Lucia, Rome, Italy.
Giustino VarrassiPaolo Procacci Foundation, Rome, Italy.
Dario BenincasaIstituto Regina Elena IFO-Neurologia, Rome, Italy.
Paolo MarchettiniIstituto Scientifico Ospedale S. Raffaele, Milan, Italy.
Marina de TommasoNeurophysiology and Pain Unit, University of Bari Aldo Moro, Bari, Italy.
Jacob ShofanyIRCCS Fondazione Santa Lucia, Rome, Italy.
Francesca AssognaLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Daniele PerottaCentro Regionale Alzheimer ASST Rhodense, Passirana di Rho Hospital, Milan, Italy.
Katie PalmerFondazione Ospedale San Camillo IRCCS, Venezia, Italia.
Antonella PaladiniDepartment of MESVA, University of L'Aquila, L'Aquila, Italy.
Fulvia di IulioIRCCS Fondazione Santa Lucia, Rome, Italy.
Carlo CaltagironeIRCCS Fondazione Santa Lucia, Rome, Italy.
Fondazione Santa Lucia · ITAziende Socio Sanitaria Territoriale RhodenseCarolinas Pain Institute · USIRCCS Ospedale San Raffaele · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale generale di zona San Camillo Treviso · ITUniversity of Bari Aldo Moro · ITUniversity of L'Aquila · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The presence of pain in elderly persons with cognitive decline is often neglected, under-reported, underestimated, misdiagnosed and not adequately treated, with consequences that have a strong impact on health, independence in activities of daily living and quality of life. There is no empirical evidence that people with dementia experience less pain; therefore, in patients with severe cognitive impairment the progression of cognitive decline dramatically affects the ability to verbalize the presence of pain. Self-assessment scales are considered the "gold standard" for pain assessment, but the presence of cognitive impairment is likely to reduce the reliability of these measures. Treatment of pain in elderly with cognitive decline or dementia is based on non-pharmacological and pharmacological strategies. Pharmacological treatment should consider physiological changes, high comorbidity and drug interactions that occur frequently in the elderly. This narrative review aims to describe current knowledge, methods of detection and treatment approaches for chronic pain in elderly persons with cognitive deficits.

Indexed as

AgingAlzheimer’s diseaseChronic painDementiaElderlyFrailty

Identifiers

PMID30666612
PMCPMC6513941
OpenAlexW2913403381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.