ArticleBiogerontology2019
Can markers of biological age predict dependency in old age?
Article in Biogerontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Association between body mass index and frailty for middle-aged and older adults in Japan: a cross-sectional study of the Osaka health disparity solution program.BMC public health · 2026Article
- The incremental predictive value of biological aging indicators for cognitive impairment in older adults: a longitudinal analysis on the Mr. OS & Ms. OS cohort.Alzheimer's research & therapy · 2025Article
- Does polypharmacy affect epigenetic aging in older people? Evidence from a longitudinal epigenome-wide methylation study.Clinical epigenetics · 2025Article
- Epigenetic Biomarkers of Cardiovascular Risk in Frail Patients-A Scope Review.Current issues in molecular biology · 2025Review
- Association between mobile phone, self-efficacy and dependency among elderly people: a community-based study.mHealth · 2025Article
- A scoping review to examine health care professionals' experiences as family caregivers.PloS one · 2025Article
- Association between community environment and dependency among the elderly people from a service provision perspective.BMC geriatrics · 2022Article
- Epigenetic Age Acceleration and Change in Frailty in MOBILIZE Boston.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Frailty in individuals with depression, bipolar disorder and anxiety disorders: longitudinal analyses of all-cause mortality.BMC medicine · 2022Article
- Seven-CpG DNA Methylation Age Determined by Single Nucleotide Primer Extension and Illumina's Infinium MethylationEPIC Array Provide Highly Comparable Results.Frontiers in genetics · 2021Article
- Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex.Brain : a journal of neurology · 2020Article
- Anti-aging technoscience & the biologization of cumulative inequality: Affinities in the biopolitics of successful aging.Journal of aging studies · 2020Article
- Associations of annual ambient PMEnvironmental pollution (Barking, Essex : 1987) · 2020Article
- Associations between a laboratory frailty index and adverse health outcomes across age and sex.Aging medicine (Milton (N.S.W)) · 2019Article
- Frailty and Intrinsic Capacity: Two Distinct but Related Constructs.Frontiers in medicine · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Recent research has shown that markers of biological age, such as leukocyte telomere length (LTL), epigenetic clocks and the frailty index (FI) are predictive of mortality and age-related diseases. However, whether these markers associate with the need for care in old age, thereby having utility in reflecting dependency, is unclear. This study was undertaken to analyze whether LTL, two epigenetic clocks-the DNA methylation age (DNAmAge) and DNAm PhenoAge-and the FI are associated with the need for regular care in up to 604 individuals (aged 48-94 years) participating in the Swedish Adoption/Twin Study of Aging. Need for regular care was defined as receiving formal or informal help in daily routines at least once per week. Logistic regression adjusted for age, sex and education was used in the analysis. The predictive accuracies, assessed as the area under the curve (AUC) for the significant biological age measures were further compared to the accuracies of the limitations in activities of daily living (ADL) and instrumental ADL (IADL). Neither LTL nor the epigenetic clocks were associated with the need for care, whereas the FI was; odds ratio for 10% increase in FI 3.54 (95% confidence interval 2.32-5.41). The FI also demonstrated higher predictive accuracy than the ADL score (FI AUC 0.80 vs. ADL score AUC 0.62; p < 0.001 for equality of the AUCs), whereas the difference between FI AUC (0.80) and IADL score AUC (0.75) was not significant (p = 0.238). The FI might thus be a useful marker for the need for care.
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