Evidence map›Paper›PMID 30666513›Full record

ArticleEJNMMI research2019

Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using

Zohreh Varasteh, Sarajo Mohanta, Yuanfang Li, Nicolás López Armbruster, Miriam Braeuer, Stephan G Nekolla, Andreas Habenicht, Hendrik B Sager, Geert Raes, Wolfgang Weber and 2 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Preclinical techniques to investigate exercise training in vascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021
    Pooled it
  2. Article
  3. Imaging of tumor-associated macrophage dynamics during immunotherapy using a CD163-specific nanobody-based immunotracer.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Review
  5. Review
  6. Article
  7. Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  8. Review
  9. Review
  10. Phase I Study of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  11. Article
  12. Article
  13. NANOBODIES®: A Review of Diagnostic and Therapeutic ApplicationsInternational journal of molecular sciences · 2023
    Review
  14. Targeting Immune Senescence in Atherosclerosis.International journal of molecular sciences · 2022
    Review
  15. Single-Domain Antibody Theranostics on the Horizon.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Frontiers in cardiovascular medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Zohreh VarastehDepartment of Nuclear Medicine, Klinikum rechts der Isar der TUM, Ismaninger-Strasse 22, 81675, Munich, Germany. zohreh.varasteh@tum.de.
Sarajo MohantaInstitute for Cardiovascular Prevention, University Hospital of Ludwig-Maximilians-University, Munich, Germany.
Yuanfang LiInstitute for Cardiovascular Prevention, University Hospital of Ludwig-Maximilians-University, Munich, Germany.
Nicolás López ArmbrusterDeutsches Herzzentrum München, Klinik für Herz und Kreislauferkrankungen, Technical University of Munich, Munich, Germany.
Miriam BraeuerDepartment of Nuclear Medicine, Klinikum rechts der Isar der TUM, Ismaninger-Strasse 22, 81675, Munich, Germany.
Stephan G NekollaDepartment of Nuclear Medicine, Klinikum rechts der Isar der TUM, Ismaninger-Strasse 22, 81675, Munich, Germany.
Andreas HabenichtInstitute for Cardiovascular Prevention, University Hospital of Ludwig-Maximilians-University, Munich, Germany.
Hendrik B SagerDeutsches Herzzentrum München, Klinik für Herz und Kreislauferkrankungen, Technical University of Munich, Munich, Germany.
Geert RaesDepartment of Bio-engineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Wolfgang WeberDepartment of Nuclear Medicine, Klinikum rechts der Isar der TUM, Ismaninger-Strasse 22, 81675, Munich, Germany.
Sophie HernotIn Vivo Cellular and Molecular Imaging (ICMI), Vrije Universiteit Brussel, Brussels, Belgium.
Markus SchwaigerDepartment of Nuclear Medicine, Klinikum rechts der Isar der TUM, Ismaninger-Strasse 22, 81675, Munich, Germany.
Klinikum rechts der Isar · DELudwig-Maximilians-Universität München · DEVrije Universiteit Brussel · BEMünchen Klinik · DETechnical University of Munich · DE

Funding

Deutsche Forschungsgemeinschaft (DFG) HA 1083/15-4Deutsche Forschungsgemeinschaft (DFG) MO 3054/1-1Deutsches Zentrum für Herz-Kreislaufforschung (DZHK): 81Z6600661European Union Seventh Framework Program (FP7) 294582 ERC Grant MUMIResearch Foundation Flanders FWO G005815N
6 · The paper itself

Abstract

backgroundRupture-prone atherosclerotic plaques are characterized by heavy macrophage infiltration, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The mannose receptor (MR, CD206) is over-expressed in several types of alternatively activated macrophages. In this study, our objective was to evaluate the feasibility of a Gallium-68 (

resultsNOTA-anti-MMR Nb was labelled with

conclusions

Indexed as

Alternatively differentiated macrophagesAtherosclerotic plaquesInflammationMannose receptorNon-invasive imagingPET/CT

Identifiers

PMID30666513
PMCPMC6340911
OpenAlexW2922712716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.