Evidence map›Paper›PMID 30666489›Full record

ArticleCancer causes & control : CCC2019

Body mass index modifies bladder cancer risk associated with low estrogen exposure among Egyptian women after menopause.

Sania Amr, Beverly J Wolpert, Diane Marie St George, India James, Christopher A Loffredo

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sania AmrDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, 660 West Redwood Street HH 109, Baltimore, MD, 21201, USA. samr@som.umaryland.edu.ORCID http://orcid.org/0000-0002-1193-877X
Beverly J WolpertU.S. Food and Drug Administration (FDA), Center for Food Safety and Applied Nutrition, College Park, MD, USA.
Diane Marie St GeorgeDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, 660 West Redwood Street HH 109, Baltimore, MD, 21201, USA.
India JamesU.S. Food and Drug Administration (FDA), Center for Food Safety and Applied Nutrition, College Park, MD, USA.
Christopher A LoffredoLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Center for Food Safety and Applied Nutrition · USUniversity of Maryland, Baltimore · USGeorgetown University · US

Funding

Gender Differences in Bladder Cancer Risk FactorsR01CA115618 · NCI · GEORGETOWN UNIVERSITY · PI LOFFREDO, CHRISTOPHER A · 2006 to 2010
$2.2M
National Institutes of Health (US) R01-CA115618NCI NIH HHS R01 CA115618
6 · The paper itself

Abstract

purposeInvestigators have reported inconsistent findings regarding associations between body mass index (BMI) and bladder cancer risk, and they have postulated that sex steroids mediate such associations. We assessed the impact of BMI on the relationship between bladder cancer risk and combinations of age at first childbirth, parity, and age at menopause, among Egyptian women.

methodsWe used data from our multicenter case-control study of 419 cases and 786 controls in logistic regression models to estimate adjusted odds ratios (AORs) and 95% confidence intervals (CIs) of such associations.

resultsAge > 18 years at first childbirth and parity ≤ 6 were significantly associated with bladder cancer risk, which was higher when both factors (AOR = 2.31, 95% CI = 1.55-3.43) and age at menopause < 45 years (AOR = 3.51, 95% CI = 1.88-6.55) were present. Early menopause was associated with higher bladder cancer risk in obese (AOR = 2.90, 95% CI = 1.40-5.98) but not normal weight women (AOR = 0.98, 95% CI = 0.58-1.65; P

conclusionBody mass index appears to modify bladder cancer risk in Egyptian women after menopause by slightly enhancing the risk associated with low estrogen exposure among the obese only. Longitudinal studies of the BMI role in bladder malignancy in this distinctive population are required.

Indexed as

Body Mass IndexMenopauseAdultAgedCase-Control StudiesEgyptEstrogensFemaleHumansLogistic ModelsMaleMiddle AgedObesityOdds RatioOverweightParityEstrogensBladder cancerBody mass indexEarly menopauseEgyptian womenEstrogen exposure

Identifiers

PMID30666489
PMCPMC6690206
OpenAlexW2911649671

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.