Evidence map›Paper›PMID 30666346›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2019

Follicular helper T cell and memory B cell immunity in CHC patients.

Yong Liu, Huifan Ji, Pingwei Zhao, Hongqing Yan, Yanjun Cai, Lei Yu, Xiaoli Hu, Xiguang Sun, Yanfang Jiang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yong LiuGenetic Diagnosis Center, The First Hospital of Jilin University, Changchun, 130021, China.
Huifan JiDepartment of Hepatology, The First Hospital of Jilin University, Changchun, China.
Pingwei ZhaoGenetic Diagnosis Center, The First Hospital of Jilin University, Changchun, 130021, China.
Hongqing YanDepartment of Hepatology, The First Hospital of Jilin University, Changchun, China.
Yanjun CaiDepartment of Hepatology, The First Hospital of Jilin University, Changchun, China.
Lei YuDepartment of Infectious Disease, The Fourth Hospital of Harbin Medical University, Harbin, China.
Xiaoli HuDepartment of Infectious Disease, Heilongjiang Provincial Hospital, Harbin, China.
Xiguang SunGenetic Diagnosis Center, The First Hospital of Jilin University, Changchun, 130021, China.
Yanfang JiangGenetic Diagnosis Center, The First Hospital of Jilin University, Changchun, 130021, China. yanfangjiang@hotmail.com.
First Hospital of Jilin University · CNFourth Affiliated Hospital of Harbin Medical University · CNHeilongjiang Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic hepatitis C (CHC) is associated with biological activity of T follicular helper (Tfh) cells and memory B cells (MBCs). However, the nature of Tfh cell subsets that are responsible for MBCs in CHC patients has not been evaluated. This study aimed to investigate Tfh and MBC immunity before and after direct-acting antiviral (DAA) therapy in patients with CHC. A total of 31 CHC patients and 15 healthy controls (HCs) were recruited. Individual patients were treated with sofosbuvir/ribavirin (SOF/RBV) or in combination with pegylated interferon alpha-2a (PEG-IFN-α-2a) for 12 weeks. Immunofluorescence revealed the frequency of ICOS

Indexed as

Antiviral AgentsB-LymphocytesCells, CulturedCoculture TechniquesDrug Therapy, CombinationFemaleHepatitis C, ChronicHumansInterferon-alphaMalePolyethylene GlycolsRecombinant ProteinsRibavirinSofosbuvirT-Lymphocytes, Helper-InducerAntiviral AgentsInterferon-alphapeginterferon alfa-2aPolyethylene GlycolsRecombinant ProteinsRibavirinSofosbuvirAntiviral treatmentChronic hepatitis CImmune responseMemory B cellT follicular helper cell

Identifiers

PMID30666346
OpenAlexW2912088702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.