Evidence map›Paper›PMID 30666283›Full record

ArticleCurrent hepatology reports2018

Long-Term Outcomes After Drug-Induced Liver Injury.

Paul H Hayashi, Einar S Bjornsson

Abstract read
In one paragraph

Article in Current hepatology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Drug-induced liver injury.Yeungnam University journal of medicine · 2020
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Paul H Hayashidivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina.
Einar S BjornssonDivision of Gastroenterology and Hepatology, The National University Hospital of Iceland, Reykjavik, Iceland.

Funding

University of North Carolina Clinical Center for DILINU01DK065201 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PAUL B WATKINS · 2003 to 2026
$7.3M
Right Lobe Living Donor Liver Transplantation in AdultsU01DK062505 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAYASHI, PAUL HIDEYO · 2002 to 2010
$1.2M
NIDDK NIH HHS U01 DK062505NIDDK NIH HHS U01 DK065201
6 · The paper itself

Abstract

purpose of the reviewThis review serves to update the reader on emerging data regarding a spectrum of drug-induced liver injury (DILI) outcomes that lie between complete resolution and acute liver failure. Such outcomes can range from mild chronic injury to late liver failure and mortality. RECENT

findingsSeveral large registries are maturing with large numbers of DILI cases thus shedding light on outcomes including chronic injury and late fatality. We cover definitions commonly used to describe resolution versus chronic injury and mortality due to DILI. We look at rates of occurrence for these different outcomes in major registries. Three specific types of chronic DILI that are illustrative but also easily missed by clinicians are also described. SUMMARY: A small but important proportion of DILI cases do not resolve, going on to develop chronic injury and even liver failure. Defining and recognizing these cases is a challenge because DILI is rare, and chronic injury rarer still. Large registries are beginning to define these previously overlooked long term outcomes.

Indexed as

chronichepatotoxicityliver failuremortalitytransplant

Identifiers

PMID30666283
PMCPMC6337717

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.