Evidence map›Paper›PMID 30665891›Full record

ArticleJournal of cell science2019

BBS4 is required for intraflagellar transport coordination and basal body number in mammalian olfactory cilia.

Cedric R Uytingco, Corey L Williams, Chao Xie, Dana T Shively, Warren W Green, Kirill Ukhanov, Lian Zhang, Darryl Y Nishimura, Val C Sheffield, Jeffrey R Martens

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

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  17. Gene therapy rescues olfactory perception in a clinically relevant ciliopathy model of Bardet-Biedl syndrome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  18. Aquatic models of human ciliary diseases.Genesis (New York, N.Y. : 2000) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Cedric R UytingcoDepartment of Pharmacology and Therapeutics, Gainesville, FL 32610, USA.ORCID 0000-0003-1625-3988
Corey L WilliamsDepartment of Pharmacology and Therapeutics, Gainesville, FL 32610, USA.
Chao XieDepartment of Pharmacology and Therapeutics, Gainesville, FL 32610, USA.
Dana T ShivelyDepartment of Pharmacology and Therapeutics, Gainesville, FL 32610, USA.
Warren W GreenDepartment of Pharmacology and Therapeutics, Gainesville, FL 32610, USA.
Kirill UkhanovDepartment of Pharmacology and Therapeutics, Gainesville, FL 32610, USA.ORCID 0000-0003-0633-9067
Lian ZhangDepartment of Pharmacology and Therapeutics, Gainesville, FL 32610, USA.
Darryl Y NishimuraDepartment of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.
Val C SheffieldDepartment of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.
Jeffrey R MartensDepartment of Pharmacology and Therapeutics, Gainesville, FL 32610, USA martensj@ufl.edu.ORCID 0000-0002-0451-2703
University of Florida · USUniversity of Iowa · US

Funding

Interdisciplinary approach to retinal disease gene identificationR01EY017168 · NEI · UNIVERSITY OF IOWA · PI SHEFFIELD, VAL C. · 2007 to 2017
$5.9M
Olfactory Singaling, Cilia, and Sensory DisordersR01DC009606 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARTENS, JEFFREY · 2008 to 2018
$4.1M
NEI NIH HHS R01 EY017168NIDCD NIH HHS R01 DC009606
6 · The paper itself

Abstract

Bardet-Beidl syndrome (BBS) manifests from genetic mutations encoding for one or more BBS proteins. BBS4 loss impacts olfactory ciliation and odor detection, yet the cellular mechanisms remain unclear. Here, we report that

Indexed as

AnimalsBardet-Biedl SyndromeBasal BodiesCells, CulturedCiliaDisease Models, AnimalFlagellaHumansMiceMice, Inbred C57BLMice, KnockoutMicrotubule-Associated ProteinsOlfactory Receptor NeuronsPhenotypeProtein TransportSmellBBS4 protein, mouseMicrotubule-Associated ProteinsTrimethoprim, Sulfamethoxazole Drug CombinationTubulinBardet–Biedl syndromeBasal bodyGene therapyIntraflagellar transportOlfactory ciliaPeripheral olfactory system

Identifiers

PMID30665891
PMCPMC6432715
OpenAlexW2910002973

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.