Evidence map›Paper›PMID 30665714›Full record

Trial reportSchizophrenia research2019

Impact of baseline early auditory processing on response to cognitive remediation for schizophrenia.

Alice Medalia, Alice M Saperstein, Min Qian, Daniel C Javitt

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01945333 (Personalized and Scalable Cognitive Remediation Approaches), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01945333 nacompletednot on this map

Personalized and Scalable Cognitive Remediation Approaches

TypeinterventionalSponsorNew York State Psychiatric InstituteRan2013 to 2019Enrolled115ConditionsSchizophrenia, Schizoaffective DisorderArmsCognitive remediation
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Observational
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Candidate biomarkers in psychiatric disorders: state of the field.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alice MedaliaNew York State Psychiatric Institute, Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons and New York Presbyterian, New York, NY 10032, USA. Electronic address: Alice.Medalia@columbia.edu.
Alice M SapersteinDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: Alice.Saperstein@nyspi.columbia.edu.
Min QianColumbia University Mailman School of Public Health, Department of Biostatistics, New York, NY 10032, USA. Electronic address: mq2158@cumc.columbia.edu.
Daniel C JavittNew York State Psychiatric Institute, Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: dcj2113@cumc.columbia.edu.
Columbia University · US

Funding

Personalized and Scalable Cognitive Remediation ApproachesR34MH100317 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MEDALIA, ALICE · 2013 to 2015
$735k
NIMH NIH HHS R34 MH100317
6 · The paper itself

Abstract

backgroundEarly auditory processing (EAP) has increasingly become a focus of efforts to identify biomarkers of treatment response in schizophrenia. EAP deficits lead to poor functional outcome via impaired cognition, and treatments that target EAP may drive downstream cognitive improvements. Assessment of baseline need provides an opportunity for cognitive remediation (CR) programs that give EAP training to personalize treatment and optimize its impact. This initial efficacy study examined the differential benefit of EAP training for those with and without baseline EAP deficits as defined by performance on the Tone Matching Test.

methods103 outpatient adults diagnosed with schizophrenia or schizoaffective disorder were classified as having intact (48.5%) or impaired (51.5%) EAP and randomized to a CR program with restorative exercise plans that either included EAP training (N = 49) or did not (N = 54). Cognitive and functional outcomes were measured post-treatment and 3 months later.

resultsOnly in EAP impaired participants was there a significant benefit from EAP training on verbal learning. Treatment condition did not significantly impact global cognitive or functional outcomes for either EAP group. Cognitive gains partially mediated the relationship between gains in EAP and functional capacity.

conclusionThese findings support the importance of addressing basic auditory deficits when attempting to remediate higher order auditory impairments such as verbal learning. In addition, they highlight the need for routine assessment of EAP in cognitive remediation participants, as well as the need for more effective programs to reverse these impairments.

Indexed as

Schizophrenic PsychologyAdultAgedAmbulatory CareAuditory Perceptual DisordersCognitive RemediationFemaleHumansMaleMiddle AgedPsychotic DisordersSchizophreniaSecondary PreventionYoung AdultCognitive remediationEarly auditory processingNeurocognition

Identifiers

PMID30665714
PMCPMC6739117
OpenAlexW2909849685

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.