ArticleKidney international2019
TRPC6 in diabetic kidney disease: good guy or bad guy?
Article in Kidney international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- TRPC6-Calpain-1 Axis Promotes Tubulointerstitial Inflammation by Inhibiting Mitophagy in Diabetic Kidney Disease.Kidney international reports · 2024Article
- Effects of zinc in podocytes and cortical collecting duct in vitro and Dahl salt-sensitive rats in vivo.The Journal of biological chemistry · 2024Article
- Ion channels and channelopathies in glomeruli.Physiological reviews · 2023Review
- Tacrolimus Protects Podocytes from Apoptosis via Downregulation of TRPC6 in Diabetic Nephropathy.Journal of diabetes research · 2021Article
- Ethanolic Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- [Correlation between transient receptor potential canonical channel with heart and kidney injure of rat model of obstructive sleep apnea hypopnea syndrome].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020Article
- New insight into podocyte slit diaphragm, a therapeutic target of proteinuria.Clinical and experimental nephrology · 2020Review
- Role of TRPC6 in Progression of Diabetic Kidney Disease.Current hypertension reports · 2019Review
- Ion channels and transporters in diabetic kidney disease.Current topics in membranes · 2019Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
An association of altered activity of transient receptor potential cation channel C6 (TRPC6) with the development of various diabetic complications was previously reported. In this issue, Wang et al. tested the contribution of TRPC6 in type 1 diabetes setting by breeding Akita mice with TRPC6 knockout mice. The authors revealed that the knockout of TRPC6 decreased proteinuria and attenuated tubule injury but promoted mesangial expansion in Akita mice. Therefore, TRPC6 has both beneficial and detrimental effects on glomeruli function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.