Evidence map›Paper›PMID 30665516›Full record

ArticleRespiratory medicine2019

Airway wall thickening on CT: Relation to smoking status and severity of COPD.

Jean-Paul Charbonnier, Esther Pompe, Camille Moore, Stephen Humphries, Bram van Ginneken, Barry Make, Elizabeth Regan, James D Crapo, Eva M van Rikxoort, David A Lynch and 1 more

Open access · bronzeAbstract readComparative StudyMulticenter Study
In one paragraph

Article in Respiratory medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jean-Paul CharbonnierThirona, Nijmegen, the Netherlands; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: jeanpaulcharbonnier@thirona.eu.
Esther PompeDepartment of Respiratory Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Camille MooreDepartment of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO, USA.
Stephen HumphriesDepartment of Radiology, National Jewish Health, Denver, CO, USA.
Bram van GinnekenDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Barry MakeDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Elizabeth ReganDepartment of Medicine, National Jewish Health, Denver, CO, USA.
James D CrapoDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Eva M van RikxoortThirona, Nijmegen, the Netherlands; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
David A LynchDepartment of Radiology, National Jewish Health, Denver, CO, USA.
COPDGene investigators
National Jewish Health · USRadboud University Nijmegen · NLUniversity Medical Center Utrecht · NL

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS U01 HL089897
6 · The paper itself

Abstract

Airway wall thickening in cigarette smokers is thought to be a result of inflammatory changes and airway remodeling. This study investigates if CT-derived airway wall thickening associates to disease severity in smokers with and without COPD and if airway wall thickening is reversible by smoking cessation. We examined 2000 smokers and 46 never-smokers who returned for a 5-year follow-up visit in the COPDGene-study. Multivariable regression analyses were performed at visit 1 to associate airway wall thickness (expressed as Pi10) with percent predicted forced expiratory volume in 1 s (FEV

Indexed as

AgedAirway RemodelingCross-Sectional StudiesFemaleForced Expiratory VolumeHumansLinear ModelsMaleMiddle AgedPulmonary Disease, Chronic ObstructiveQuality of LifeRegression AnalysisRespiratory Function TestsSeverity of Illness IndexSmokingSmoking CessationAirway wall inflammationComputed tomographyQuality of lifeSmoking cessation

Identifiers

PMID30665516
PMCPMC6639031
OpenAlexW2901567758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.