ArticleAIDS research and therapy2019
What causes non-adherence among some individuals on long term antiretroviral therapy? Experiences of individuals with poor viral suppression in Uganda.
Article in AIDS research and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
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Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- A conceptual model of alcohol use and adherence to antiretroviral therapy: systematic review and theoretical implications for mechanisms of action.Health psychology review · 2022Pooled it
- Predictors of Treatment Adherence and Virological Failure Among People Living with HIV Receiving Antiretroviral Therapy in a South African Rural Community: A Sub-study of the ITREMA Randomised Clinical Trial.AIDS and behavior · 2023Trial
- Comparing the effect of a multisectoral agricultural intervention on HIV-related health outcomes between widowed and married women.Social science & medicine (1982) · 2023Trial
- Financial incentives to improve re-engagement in HIV care: results from a randomized pilot study.AIDS care · 2023Trial
- Trial
- "The one who doesn't take ART medication has no wealth at all and no purpose on Earth" - a qualitative assessment of how HIV-positive adults in Uganda understand the health and wealth-related benefits of ART.BMC public health · 2022Trial
- Habit formation in support of antiretroviral medication adherence in clinic-enrolled HIV-infected adults: a qualitative assessment using free-listing and unstructured interviewing in Kampala, Uganda.AIDS research and therapy · 2020Trial
- Brief communication: clinical jaundice is associated with poor adherence to boosted atazanavir among adults in an HIV clinic in Kampala, Uganda.AIDS research and therapy · 2026Article
- Real-world adherence, persistence, and health care resource utilization among people with HIV receiving long-acting cabotegravir plus rilpivirine compared with oral antiretroviral therapy in the United States: The ABOVE Study.Journal of managed care & specialty pharmacy · 2026Article
- Poor adherence to second-line antiretroviral therapy and its contributing factors among people living with HIV in Addis Ababa, Ethiopia.AIDS research and therapy · 2026Article
- Prevalence and Factors Associated with Non-Adherence To Anti-retroviral Therapy among People Living with HIV.Journal of community health · 2026Article
- Virological failure and risk factors among people living with HIV taking second-line ART in Addis Ababa, Ethiopia.PloS one · 2026Article
- Illness Experience and Unmet Needs of Pulmonary Tuberculosis Patients: A Meta-Synthesis Guided by the Symptom Experience Model.Patient preference and adherence · 2026Review
- Antiretroviral therapy clients' experience of Follow-up care in tshwane, Gauteng province, South Africa.AIDS research and therapy · 2025Article
- Healthcare workers' perception of quality of care rendered to people living with HIV and non-communicable diseases at an urban district hospital in KwaZulu Natal, South Africa: a mixed mode study.BMC health services research · 2025Article
- Potential impact and cost-effectiveness of long-acting injectable lenacapavir plus cabotegravir as HIV treatment in Africa.Nature communications · 2025Article
- Cognitive behavioral therapy for antiretroviral therapy adherence and treatment outcomes among people living with HIV: a systematic review and meta-analysis.Nature. Mental health · 2025Article
- Experiences of nurses in patient adherence to antiretoroviral therapy in Mpumalanga, South Africa.African journal of primary health care & family medicine · 2025Article
- Experiences of people living with HIV/AIDS in selected hospitals in Imo state, Nigeria, regarding the usability and satisfaction of reminders using M-health features: a qualitative study.Scientific reports · 2025Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
backgroundAntiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. Good ART adherence is required to achieve these benefits. We investigated how the environmental, social, economic and behavioural experiences of people living with HIV with poor viral suppression could explain their non-adherence to long term ART.
methodsThis qualitative cross-sectional study was conducted in Uganda between September 2015 and April 2016. Thirty individuals on ART for 5 years or more (10 on first line and 20 on second line), with poor viral suppression, were randomly selected from a cohort of people living with HIV on ART. In-depth interviews about ART; awareness, adherence counselling, obstacles to daily adherence and regimen switches were conducted. Emerging themes from the interviews transcripts and field notes were identified and thematic content analysis done. Participants' consent, compensation, confidentiality and study ethical approvals were ensured.
resultsWe found that poor adherence to long term ART was due to: travel for work or social activities, stigma, receiving little or no continuous ART adherence education, alcohol consumption and use of alternative 'HIV cure' medicines. Other reasons included; ART side effects, treatment fatigue, belief that long-term ART or God can 'cure HIV', and food security.
conclusionsAchieving optimal ART benefits requires continuous provision of ART adherence education to individuals on long term ART. This helps them overcome the challenges related to living with HIV: worries of food insecurity, alcohol misuse, economic hardship, and beliefs in HIV cures and use of unproven alternative HIV treatments. People living with HIV who travel require adherence support and larger quantities of ART refills to cover their time away.
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