ArticleBMC gastroenterology2019
Helicobacter pylori infection associated with an increased risk of colorectal adenomatous polyps in the Chinese population.
Article in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Association BetweenFrontiers in medicine · 2021Pooled it
- Association between Helicobacter pylori infection and the risk of colorectal cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Risk for Colorectal Neoplasia in Patients With Helicobacter pylori Infection: A Systematic Review and Meta-analysis.Clinical and translational gastroenterology · 2020Pooled it
- Efficacy of Lactobacillus-supplemented triple therapy for H. pylori eradication: A meta-analysis of randomized controlled trials.PloS one · 2019Pooled it
- Beyond the Stomach: Exploring the Role ofExpert reviews in molecular medicine · 2026Review
- Article
- Increased risk of colorectal adenoma and benign colorectal polyp associated withTranslational cancer research · 2025Article
- Relationship betweenAging · 2024Article
- Serum microRNA Levels as a Biomarker for Diagnosing Non-Alcoholic Fatty Liver Disease in Chinese Colorectal Polyp Patients.International journal of molecular sciences · 2023Article
- Tumor Microenvironment Shapes Colorectal Cancer Progression, Metastasis, and Treatment Responses.Frontiers in medicine · 2022Review
- Association of D299G Polymorphism of TLR4 Gene and CagA Virulence Factor of H. pylori among the Iranian Patients with Colorectal Cancer.Medical journal of the Islamic Republic of Iran · 2022Article
- Establish a Novel Model for Predicting the Risk of Colorectal Ademomatous Polyps: a Prospective Cohort Study.Journal of Cancer · 2022Article
- Results of endoscopy in 35,525 patients with precancerous diseases of the gastrointestinal tract.International journal of clinical and experimental pathology · 2021Article
- Polarization of intestinal tumour-associated macrophages regulates the development of schistosomal colorectal cancer.Journal of Cancer · 2021Article
- Association ofWorld journal of gastrointestinal oncology · 2020Article
- Comparison of the clinicopathological features and prognoses of patients with schistosomal and nonschistosomal colorectal cancer.Oncology letters · 2020Article
- Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota.Frontiers in cellular and infection microbiology · 2020Review
- Effect of Gender and Age on the Correlation between Helicobacter pylori and Colorectal Adenomatous Polyps in a Chinese Urban Population: A Single Center Study.Gastroenterology research and practice · 2020Article
- Helicobacter pylori and colorectal cancer-A bacterium going abroad?PLoS pathogens · 2019Article
- Correlation between Colon Polyps and Metabolic Syndrome and HP Infection Status.Gastroenterology research and practice · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundGastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. pylori with colorectal adenomatous polyps (CAP) in the Chinese population.
methodsOne thousand three hundred seventy five workers of China Petroleum and Chemical Corporation Sinopec Zhenhai Refining & Chemical Branch were recruited. Carbon-13 urea breathes test, and colorectal biopsies were utilized to detect H. pylori and CAP. The correlation between the number and distribution of CAP with H. pylori infection (HPI) was determined. Logistic regression models were applied to calculate the effect of H. pylori on the risk of CAP and pathway studio was used to attribute the cellular processes linking HPI and adenomatous polyps.
resultsOne hundred Eighty participants were diagnosed as CAP, and 1195 participants were classified as healthy control. The prevalence of HPI in the CAP group was significantly higher than that in the healthy control group (57.8% verse 40.1%) (p<0.001). It was the number not the distribution of CAP corrected with H. pylori status. An increased risk of CAP was found to be associated with H. pylori (OR = 3.237; 95.0% CI 2.184-4.798, p = 0.00) even after multiple parameters adjustment. Pathway studio analysis demonstrated that HPI connected with CAP at multi-level.
conclusionsHPI is associated with an increased risk of CAP in the Chinese population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.