ArticleVirulence2019
Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells.
Article in Virulence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- A basophil-specific GPCR mediates the immune response to helminth infection.bioRxiv : the preprint server for biology · 2026Article
- Treatment with (R)-α-methylhistamine or IL4 stimulates mucin production and decreasesVirulence · 2025Article
- Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells.PLoS pathogens · 2025Article
- Prevalence of pathogens associated with neonatal gastrointestinal infections: a systematic review and meta-analysis.Gut pathogens · 2025Review
- Experimental trichuriasis: Changes in the immune response and bacterial translocation during acute phase development illustrated with 3D model animation.PLoS neglected tropical diseases · 2025Article
- EnterotoxigenicTransboundary and emerging diseases · 2025Article
- In vitro fish mucosal surfaces producing mucin as a model for studying host-pathogen interactions.PloS one · 2024Article
- Characteristics of mucin hypersecretion in different inflammatory patterns based on endotypes of chronic rhinosinusitis.Clinical and translational allergy · 2024Review
- Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis.The Journal of clinical investigation · 2023Article
- View from the Biological Property: Insight into the Functional Diversity and Complexity of the Gut Mucus.International journal of molecular sciences · 2023Review
- Article
- The effects of sulfated secondary bile acids on intestinal barrier function and immune response in an inflammatoryHeliyon · 2022Article
- Intestinal Barrier in Human Health and Disease.International journal of environmental research and public health · 2021Review
- The role of goblet cells in viral pathogenesis.The FEBS journal · 2021Review
- Changes in proteins related to early nerve repair in a rat model of sciatic nerve injury.Neural regeneration research · 2021Article
- Review
- Overview of Immunological Responses and Immunomodulation Properties ofLife (Basel, Switzerland) · 2021Review
- Stress Impairs Skin Barrier Function and Induces α2-3 LinkedInternational journal of molecular sciences · 2021Article
- Mucin signature as a potential tool to predict susceptibility to COVID-19.Physiological reports · 2021Review
- Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity.Journal of inflammation research · 2021Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Citrobacter rodentium infection is a murine model for pathogenic intestinal Escherichia coli infection. C. rodentium infection causes an initial decrease in mucus layer thickness, followed by an increase during clearance. We aimed to identify the cause of these changes and to utilize this naturally occurring mucus stimulus to decrease pathogen impact and inflammation. We identified that mucin production and speed of transport from Golgi to secretory vesicles at the apical surface increased concomitantly with increased mucus thickness. Of the cytokines differentially expressed during increased mucus thickness, IFN-γ and TNF-α decreased the mucin production and transport speed, whereas IL-4, IL-13, C. rodentium and E. coli enhanced these aspects. IFN-γ and TNF-α treatment in combination with C. rodentium and pathogenic E. coli infection negatively affected mucus parameters in vitro, which was relieved by IL-4 treatment. The effect of IL-4 was more pronounced than that of IL-13, and in wild type mice, only IL-4 was present. Increased expression of Il-4, Il-4-receptor α, Stat6 and Spdef during clearance indicate that this pathway contributes to the increase in mucin production. In vivo IL-4 administration initiated 10 days after infection increased mucus thickness and quality and decreased colitis and pathogen contact with the epithelium. Thus, during clearance of infection, the concomitant increase in IL-4 protects and maintains goblet cell function against the increasing levels of TNF-α and IFN-γ. Furthermore, IL-4 affects intestinal mucus production, pathogen contact with the epithelium and colitis. IL-4 treatment may thus have therapeutic benefits for mucosal healing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.