Evidence map›Paper›PMID 30665196›Full record

ArticleiScience2019

TRAIL-Expressing Monocyte/Macrophages Are Critical for Reducing Inflammation and Atherosclerosis.

Siân P Cartland, Scott W Genner, Gonzalo J Martínez, Stacy Robertson, Maaike Kockx, Ruby Cy Lin, John F O'Sullivan, Yen Chin Koay, Pradeep Manuneedhi Cholan, Melkam A Kebede and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

Siân P CartlandHeart Research Institute, 7 Eliza St, Newtown, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia.
Scott W GennerHeart Research Institute, 7 Eliza St, Newtown, Sydney, Australia.
Gonzalo J MartínezSydney Medical School, University of Sydney, Sydney, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia; División de Enfermedades Cardiovasculares, Pontificia Universidad Católica de Chile, Santiago, Chile.
Stacy RobertsonHeart Research Institute, 7 Eliza St, Newtown, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia.
Maaike KockxANZAC Research Institute, Sydney, Australia.
Ruby Cy LinSchool of Medical Sciences, University of New South Wales, Sydney, Australia.
John F O'SullivanHeart Research Institute, 7 Eliza St, Newtown, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia.
Yen Chin KoayHeart Research Institute, 7 Eliza St, Newtown, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia.
Pradeep Manuneedhi CholanHeart Research Institute, 7 Eliza St, Newtown, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia.
Melkam A KebedeCharles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, Australia.
Andrew J MurphyBaker Heart and Diabetes Institute, Melbourne, Australia.
Seth MastersWalter and Elisa Hall Institute of Medical Research, Melbourne, Australia.
Martin R BennettDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.
Wendy JessupANZAC Research Institute, Sydney, Australia.
Leonard KritharidesANZAC Research Institute, Sydney, Australia.
Carolyn GeczyHeart Research Institute, 7 Eliza St, Newtown, Sydney, Australia; School of Medical Sciences, University of New South Wales, Sydney, Australia.
Sanjay PatelHeart Research Institute, 7 Eliza St, Newtown, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia.
Mary M KavurmaHeart Research Institute, 7 Eliza St, Newtown, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia. Electronic address: mary.kavurma@hri.org.au.
The Heart Research Institute · AUUniversity of Sydney · AUAnzac Research Institute · AURoyal Prince Alfred Hospital · AUBaker Heart and Diabetes Institute · AUUniversity of Cambridge · GBUNSW Sydney · AUWalter and Eliza Hall Institute of Medical Research · AU

Funding

British Heart Foundation RG/13/14/30314
6 · The paper itself

Abstract

Circulating tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) levels are reduced in patients with cardiovascular disease, and TRAIL gene deletion in mice exacerbates atherosclerosis and inflammation. How TRAIL protects against atherosclerosis and why levels are reduced in disease is unknown. Here, multiple strategies were used to identify the protective source of TRAIL and its mechanism(s) of action. Samples from patients with coronary artery disease and bone-marrow transplantation experiments in mice lacking TRAIL revealed monocytes/macrophages as the main protective source. Accordingly, deletion of TRAIL caused a more inflammatory macrophage with reduced migration, displaying impaired reverse cholesterol efflux and efferocytosis. Furthermore, interleukin (IL)-18, commonly increased in plasma of patients with cardiovascular disease, negatively regulated TRAIL transcription and gene expression, revealing an IL-18-TRAIL axis. These findings demonstrate that TRAIL is protective of atherosclerosis by modulating monocyte/macrophage phenotype and function. Manipulating TRAIL levels in these cells highlights a different therapeutic avenue in the treatment of cardiovascular disease.

Indexed as

DiabetologyImmune ResponseImmunologyMolecular Mechanism of BehaviorPathophysiology

Identifiers

PMID30665196
PMCPMC6348195
OpenAlexW2907794400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.