Evidence map›Paper›PMID 30664897›Full record

ArticlePharmacology, biochemistry, and behavior2019

Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats.

Patrick A Randall, Brayden Fortino, Y Wendy Huynh, Brady M Thompson, Christopher E Larsen, Mackenzie P Callen, Scott T Barrett, Jennifer E Murray, Rick A Bevins, Joyce Besheer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Age- and Sex-Dependent Nicotine Pretreatment Effects on the Enhancement of Methamphetamine Self-administration in Sprague-Dawley Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Article
  3. Article
  4. Considering Drug-Associated Contexts in Substance Use Disorders and Treatment Development.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Patrick A RandallBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Brayden FortinoBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Y Wendy HuynhDepartment of Psychology, University of Nebraska at Lincoln, Lincoln, NE 68588, USA.
Brady M ThompsonDepartment of Psychology, University of Nebraska at Lincoln, Lincoln, NE 68588, USA.
Christopher E LarsenDepartment of Psychology, University of Nebraska at Lincoln, Lincoln, NE 68588, USA.
Mackenzie P CallenDepartment of Psychology, University of Nebraska at Lincoln, Lincoln, NE 68588, USA.
Scott T BarrettDepartment of Psychology, University of Nebraska at Lincoln, Lincoln, NE 68588, USA.
Jennifer E MurrayDepartment of Psychology, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
Rick A BevinsDepartment of Psychology, University of Nebraska at Lincoln, Lincoln, NE 68588, USA.
Joyce BesheerBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: jbesheer@med.unc.edu.
University of Nebraska–Lincoln · USUniversity of North Carolina at Chapel Hill · USUniversity of Guelph · CA

Funding

Interplay between interoception, learning, and drug seekingR21DA039356 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BESHEER, JOYCE, BEVINS, RICK A · 2016 to 2017
$420k
NIDA NIH HHS R21 DA039356
6 · The paper itself

Abstract

backgroundSmoking constitutes a significant public health risk. Alcohol and methamphetamine use disorders are also highly co-morbid with smoking, further increasing negative health outcomes. An important question in determining the underlying neurobiology of nicotine poly-drug use is understanding whether having a positive history with nicotine effects alters later drug-taking behavior.

methodsThe current experiments sought to elucidate whether having an appetitive nicotine conditioning history would affect later alcohol or methamphetamine self-administration. Adult male and female Long-Evans rats were first trained on a discriminated goal-tracking task in which the interoceptive effects of nicotine predicted sucrose reinforcement. As a control, pseudo-conditioned groups were included that had equated nicotine and sucrose experience. Rats were then shifted to either alcohol self-administration or methamphetamine self-administration.

resultsNicotine conditioning history had no effect on acquisition or maintenance of alcohol self-administration in males or females. In contrast, an appetitive nicotine conditioning history decreased methamphetamine self-administration in female rats, but not males.

conclusionsIn female, but not male, rats, an appetitive conditioning history with nicotine decreases methamphetamine, but not alcohol, self-administration. This dissociation suggests that the effects may be due to a specific increase in the reinforcing value of methamphetamine. This may have implications for better understanding the progression of drug use from nicotine to methamphetamine.

Indexed as

Conditioning, OperantAnimalsEthanolFemaleMaleMethamphetamineNicotineRatsRats, Long-EvansSelf AdministrationEthanolMethamphetamineNicotine

Identifiers

PMID30664897
PMCPMC6435414
OpenAlexW2910846152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.