Evidence map›Paper›PMID 30664876›Full record

ArticleGastroenterology2019

Hepatitis D Virus-Specific CD8

Helenie Kefalakes, Christopher Koh, John Sidney, Georgios Amanakis, Alessandro Sette, Theo Heller, Barbara Rehermann

Open access · greenAbstract read
In one paragraph

Article in Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Hepatitis Delta Virus and Hepatocellular Carcinoma.Pathogens (Basel, Switzerland) · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Liver-Resident Bystander CD8Gastroenterology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Helenie KefalakesImmunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.
Christopher KohTranslational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.
John SidneyLa Jolla Institute of Immunology, La Jolla, California.
Georgios AmanakisLaboratory of Cardiac Physiology, Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.
Alessandro SetteLa Jolla Institute of Immunology, La Jolla, California.
Theo HellerTranslational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.
Barbara RehermannImmunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland. Electronic address: Rehermann@nih.gov.
National Institutes of Health · USLa Jolla Institute for Immunology · US

Funding

Regulation of hepatic and systemic immune responsesZIADK054508 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REHERMANN, BARBARA · 2009 to 2025
$22.1M
Immunology of Acute and Chronic Viral Hepatitis in HumansZIADK054509 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REHERMANN, BARBARA · 2009 to 2025
$15.1M
Investigation of management and disease manifestations of viral hepatitisZIADK054514 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HELLER, THEO · 2009 to 2025
$12.9M
Management and Treatment of Chronic Delta Hepatitis Infection and other Liver DiseasesZIADK075150 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KOH, CHRISTOPHER · 2019 to 2025
$2.8M
Immunology of Acute and Chronic Viral Hepatitis in HumansZ01DK054509 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REHERMANN, BARBARA · 1998 to 2008
$790k
Role of the innate immune defenses in viral infectionsZ01DK054516 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REHERMANN, BARBARA · 2007 to 2008
$775k
Intramural NIH HHS Z01 DK054509Intramural NIH HHS Z01 DK054516Intramural NIH HHS ZIA DK054508Intramural NIH HHS ZIA DK054509
6 · The paper itself

Abstract

BACKGROUND &

aimHepatitis D virus (HDV) superinfection of patients with chronic HBV infection results in rapid progression to liver cirrhosis. Little is known about HDV-specific T cells and how they contribute to the antiviral immune response and liver disease pathogenesis.

methodsWe isolated peripheral blood mononuclear cells from 28 patients with chronic HDV and HBV infection, identified HDV-specific CD8

resultsWe identified 6 CD8

conclusionsCD8

Indexed as

Epitopes, T-LymphocyteAdultCD8-Positive T-LymphocytesCells, CulturedCytomegalovirusFemaleHepatitis B, ChronicHepatitis B virusHepatitis D, ChronicHepatitis delta AntigensHepatitis Delta VirusHerpesvirus 4, HumanHLA-A AntigensHLA-B AntigensHumansImmunologic MemoryEpitopes, T-LymphocyteHepatitis delta AntigensHLA-A AntigensHLA-B AntigensInterferon-gammaInterleukin-7 Receptor alpha SubunitPDCD1 protein, humanPeptidesProgrammed Cell Death 1 ReceptorLymphocyteMutationTranscription FactorVirus Escape

Identifiers

PMID30664876
PMCPMC7367679
OpenAlexW2910693465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.