Evidence map›Paper›PMID 30664861›Full record

ArticleThe American journal of pathology2019

Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of c-Jun NH2-Terminal Kinases 1 and 2.

Veronica Ulici, Kathryn L Kelley, Lara Longobardi, Margaret A McNulty, Eric W Livingston, Ted A Bateman, Cheryle A Séguin, Craig R Louer, Richard F Loeser

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Reply.Arthritis & rheumatology (Hoboken, N.J.) · 2020
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Veronica UliciDivision of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Kathryn L KelleyDivision of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Lara LongobardiDivision of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Margaret A McNultyDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana.
Eric W LivingstonJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Ted A BatemanJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Cheryle A SéguinDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Bone and Joint Institute, The University of Western Ontario, London, Ontario, Canada.
Craig R LouerDepartment of Orthopedic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Richard F LoeserDivision of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: richard_loeser@med.unc.edu.
University of North Carolina at Chapel Hill · USIndiana University School of MedicineWestern University · CA

Funding

Integrin Function in CartilageR37AR049003 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LOESER, RICHARD F · 2012 to 2021
$4.1M
NIAMS NIH HHS R37 AR049003
6 · The paper itself

Abstract

Mitogen-activated protein kinases, including c-Jun NH2-terminal kinase (JNK), play an important role in the development and function of a large variety of tissues. The skeletal phenotype of JNK1 and JNK2 double-knockout (dKO) mice (JNK1

Indexed as

Spinal FusionAnimalsAnnulus FibrosusCell DifferentiationCell ProliferationCervical VertebraeChondrogenesisFemaleIntervertebral DiscMaleMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9PhenotypeMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9

Identifiers

PMID30664861
PMCPMC6446226
OpenAlexW2909269761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.