ArticleMetabolism: clinical and experimental2019
Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis.
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Article in Metabolism: clinical and experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- Failure of Hepatic Insulin Clearance via CEACAM1-Mediated Endocytosis: The Missing Physiological Link Between Proinsulin Misfolding, Hyperinsulinemia, and Metabolic Complications in Type 2 Diabetes, Obesity, and NAFLD.Problemy endokrinologii · 2026Review
- Diminished CEACAM1 level plays a critical role in age-related hepatic fibrosis.Mechanisms of ageing and development · 2025Article
- Intestinal epithelial Ceacam1 deficiency prevents steroid-refractory acute gut graft-versus-host disease.JCI insight · 2025Article
- Insights into circulating CEACAM1 in insulin clearance and disease progression: Evidence from the Portuguese PREVADIAB2 study.European journal of clinical investigation · 2024Article
- Cell-specific regulation of insulin action and hepatic fibrosis by CEACAM1.Metabolism and target organ damage · 2024Article
- Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation.Molecular metabolism · 2024Article
- Loss of CEACAM1 in hepatocytes causes hepatic fibrosis.European journal of clinical investigation · 2024Article
- TET2 regulation of alcoholic fatty liver viaiScience · 2024Article
- Article
- The Role of Cdc42 in the Insulin and Leptin Pathways Contributing to the Development of Age-Related Obesity.Nutrients · 2023Review
- A cardiac amino-terminal GRK2 peptide inhibits insulin resistance yet enhances maladaptive cardiovascular and brown adipose tissue remodeling in females during diet-induced obesity.Journal of molecular and cellular cardiology · 2023Review
- Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans.Science translational medicine · 2023Article
- Hepatic insulin receptor: new views on the mechanisms of liver disease.Metabolism: clinical and experimental · 2023Review
- Regulation of Insulin Clearance by Non-Esterified Fatty Acids.Biomedicines · 2022Review
- Reversal of obesity development in Ceacam1Obesity (Silver Spring, Md.) · 2022Article
- A Cardiac Amino-Terminal GRK2 Peptide Inhibits Maladaptive Adipocyte Hypertrophy and Insulin Resistance During Diet-Induced Obesity.JACC. Basic to translational science · 2022Article
- Aortic Fibrosis in Insulin-Sensitive Mice with Endothelial Cell-Specific Deletion ofInternational journal of molecular sciences · 2022Article
- Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance.International journal of molecular sciences · 2021Article
- Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Hilda E GhadiehDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Lucia RussoCenter for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Harrison T MuturiDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Simona S GhanemCenter for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Iyad H ManaserhCenter for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Hye Lim NohProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Sujin SukProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Jason K KimProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA; Division of Endocrinology, Metabolism and Diabetes, University of Massachusetts Medical School, Worcester, MA, USA.
Jennifer W HillCenter for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Sonia M NajjarDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA; Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA. Electronic address: najjar@ohio.edu.
University of Toledo · USUniversity of Massachusetts Chan Medical School · USOhio University · US
Funding
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Richard A Flavell · 1993 to 2026
$44.0MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MSUBSTRATES AND INSULIN RECEPTOR ENDOCYTOSISR01DK054254 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2000 to 2021
$5.8MUMass Mouse Metabolic Phenotyping Center - Metabolism CoreU2CDK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2016 to 2021
$4.6MUMass Mouse Metabolic Phenotyping CenterU24DK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2011 to 2015
$2.1MCEACAM1: A link between metabolic and cardiovascular diseasesR01HL112248 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2012 to 2016
$1.9MDefective melanocortin signaling underlying T2D-associated erectile dysfunctionR01HD081792 · NICHD · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI HILL, JENNIFER WOOTTON · 2015 to 2019
$1.6MInsulin resistance in the pathogenesis of NASHR01DK083850 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2009 to 2010
$749kNHLBI NIH HHS R01 HL112248NICHD NIH HHS R01 HD081792NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK054254NIDDK NIH HHS R01 DK083850NIDDK NIH HHS U24 DK093000NIDDK NIH HHS U2C DK093000
Abstract
backgroundCEACAM1 regulates insulin sensitivity by promoting insulin clearance. Accordingly, global C57BL/6J.Cc1
methodsLiver-specific C57BL/6J.AlbCre+Cc1
resultsLiver-specific AlbCre+Cc1
conclusionAlbCre+Cc1
Indexed as
Insulin ResistanceAnimalsCarcinoembryonic AntigenGlucose Clamp TechniqueHyperinsulinismHyperphagiaHypothalamusLipolysisLiverMiceMice, Inbred C57BLMice, KnockoutCarcinoembryonic AntigenCeacam1 protein, mouseEnergy balanceFatty acid synthaseHyperinsulinemiaHyperphagiaInsulin clearanceInsulin resistance
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.