ArticleNature methods2019
A genetically encoded near-infrared fluorescent calcium ion indicator.
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Article in Nature methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
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123citing papers in PubMed
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Who cites it
123 citing papers in PubMed.
- Recent developments of fluorescent proteins and biosensors driven by cross-disciplinary insights.Nature methods · 2026Review
- Crosstalk-free optical indicator-actuator combinations for bidirectional optogenetics.npj biomedical innovations · 2026Review
- Red-Shifted Epac-Based FRET cAMP Sensors for All-Optical cAMP Control and Multiparameter Imaging.Cells · 2026Article
- A sensitive orange fluorescent calcium ion indicator for imaging neural activity.Nature communications · 2026Article
- Adapting a Two-Photon Scanning Microscope for Simultaneous Single-Photon Imaging of an Infrared Dopamine Sensor.eNeuro · 2026Article
- Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks.Nature biotechnology · 2026Article
- Imaging the brain by traversing the skull with light and sound.Nature biomedical engineering · 2025Review
- Non-invasive large-scale imaging of concurrent neuronal, astrocytic, and hemodynamic activity with hybrid multiplexed fluorescence and magnetic resonance imaging (HyFMRI).Light, science & applications · 2025Article
- Designed optogenetic tool for bridging single-neuronal multimodal information in intact animals.Nature communications · 2025Article
- Genetically encoded sensors illuminateIBRO neuroscience reports · 2025Article
- A high-performance fluorescent sensor spatiotemporally reveals cell-type specific regulation of intracellular adenosine in vivo.Nature communications · 2025Article
- Far-red fluorescent genetically encoded calcium ion indicators.Nature communications · 2025Article
- A sensitive soma-localized red fluorescent calcium indicator for in vivo imaging of neuronal populations at single-cell resolution.PLoS biology · 2025Article
- A tunable and versatile chemogenetic near-infrared fluorescent reporter.Nature communications · 2025Article
- Principles and Design of Molecular Tools for Sensing and Perturbing Cell Surface Receptor Activity.Chemical reviews · 2025Review
- Nanophotonic-enhanced photoacoustic imaging for brain tumor detection.Journal of nanobiotechnology · 2025Review
- Multimodal fluorescence-optoacousticPhotoacoustics · 2025Article
- Quantitative approaches for studying G protein-coupled receptor signalling and pharmacology.Journal of cell science · 2025Review
- Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals.Chemical reviews · 2024Review
- Calcium Indicators with Fluorescence Lifetime-Based Signal Readout: A Structure-Function Study.International journal of molecular sciences · 2024Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors.
Yong QianDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Kiryl D PiatkevichMedia Lab and McGovern Institute for Brain Research, MIT, Cambridge, MA, USA.
Benedict Mc LarneyInstitute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-6165-7431
Ahmed S AbdelfattahJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Sohum MehtaDepartment of Pharmacology, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4764-8579
Mitchell H MurdockMedia Lab and McGovern Institute for Brain Research, MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8625-624X
Sven GottschalkInstitute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany.
Rosana S MolinaDepartment of Cell Biology and Neuroscience, Montana State University, Bozeman, MT, USA.ORCID http://orcid.org/0000-0001-7891-2462
Wei ZhangDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Yingche ChenDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Jiahui WuDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Mikhail DrobizhevDepartment of Cell Biology and Neuroscience, Montana State University, Bozeman, MT, USA.
Thomas E HughesDepartment of Cell Biology and Neuroscience, Montana State University, Bozeman, MT, USA.ORCID http://orcid.org/0000-0002-8430-070X
Jin ZhangDepartment of Pharmacology, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7145-7823
Eric R SchreiterJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Shy ShohamDepartments of Ophthalmology and of Neuroscience and Physiology, New York University Langone Health, New York City, NY, USA.ORCID http://orcid.org/0000-0003-0376-3495
Daniel RazanskyInstitute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany.
Edward S BoydenMedia Lab and McGovern Institute for Brain Research, MIT, Cambridge, MA, USA.
Robert E CampbellDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada. robert.e.campbell@ualberta.ca.ORCID http://orcid.org/0000-0003-0604-092X
Funding
Live-cell Activity Architecture in CancerR35CA197622 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jin Zhang · 2015 to 2026
$11.2MNovel Platforms for Systematic Optical Control of Complex Neural Circuits In VivoR01DA029639 · NIDA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2010 to 2023
$6.7MRedesigning General Anesthesia (Admin Supp)R01GM104948 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., BROWN, EMERY N · 2012 to 2016
$4.4MBidirectional optical-acoustic mesoscopic neural interface for image-guided neuromodulation in behaving animalsUF1NS107680 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAZANSKY, DANIEL, RINBERG, DMITRY · 2018 to 2020
$3.4MResource for Multiphoton Characterization of Genetically-Encoded ProbesU24NS109107 · NINDS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Mikhail Drobizhev · 2018 to 2026
$2.2MNorthern Lights collaboration for better 2-photon probesU01NS094246 · NINDS · MONTANA STATE UNIVERSITY - BOZEMAN · PI CAMPBELL, ROBERT E., DROBIZHEV, MIKHAIL · 2015 to 2017
$2.0MDevelopment of Protein-based Voltage ProbesU01NS090565 · NINDS · JOHN B. PIERCE LABORATORY, INC. · PI PIERIBONE, VINCENT A · 2014 to 2016
$1.7MFive-dimensional optoacoustic tomography for large-scale electrophysiology in scattering brainsR21EY026382 · NEI · TECHNICAL UNIVERSITY OF MUNICH · PI RAZANSKY, DANIEL · 2015 to 2016
$317kEvolving a two-photon bright green fluorescent protein for neuroscienceF31NS108593 · NINDS · MONTANA STATE UNIVERSITY - BOZEMAN · PI MOLINA, ROSANA SOPHIA · 2018 to 2019
$64kNCI NIH HHS R35 CA197622NEI NIH HHS R21 EY026382NIDA NIH HHS R01 DA029639NIGMS NIH HHS R01 GM104948NINDS NIH HHS F31 NS108593NINDS NIH HHS U01 NS090565NINDS NIH HHS U01 NS094246NINDS NIH HHS U24 NS109107NINDS NIH HHS UF1 NS107680
Abstract
We report an intensiometric, near-infrared fluorescent, genetically encoded calcium ion (Ca
Indexed as
AnimalsBiliverdineCalciumDNAEscherichia coliFemaleFluorescence Resonance Energy TransferFluorescent DyesGenetic VectorsHeLa CellsHippocampusHumansIonsMaleMiceMice, Inbred C57BLBiliverdineCalciumDNAFluorescent DyesIons
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.