ArticleNature neuroscience2019
Human cognition involves the dynamic integration of neural activity and neuromodulatory systems.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 256 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
256 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comprehensive investigation of predictive processing: A cross- and within-cognitive domains fMRI meta-analytic approach.Human brain mapping · 2024Pooled it
- Better together: A systematic review of studies combining magnetic resonance imaging with ecological momentary assessment.Social neuroscience · 2024Pooled it
- Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin.Molecular psychiatry · 2026Trial
- Bayesian dynamical system analysis of the effects of methylphenidate in children with attention-deficit/hyperactivity disorder: a randomized trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Molecular genetic influences on sustained attention and executive processes and their links with psychopathology in the AFFECT study.Molecular psychiatry · 2026Article
- Mapping the psychosis spectrum - imaging neurosubtypes from multiscale functional network connectivity.Molecular psychiatry · 2026Article
- A generalized scaling law reveals synchrony-driven reorganization of brain dynamics across human lifespan.PLoS computational biology · 2026Article
- Pharmacological targeting of bunyavirus-induced synaptic impairment prevents neuronal hyperexcitability.Nature communications · 2026Article
- Ongoing thoughts at rest reflect functional brain organization and behaviour.Nature human behaviour · 2026Article
- Autism Spectrum Disorder (ASD) Through the Lens of Hidden Markov Models (HMMs) Applied to Resting-State fMRI (rs-fMRI): A Systematic Review and Meta-analysis.Journal of autism and developmental disorders · 2026Article
- Frequency-specific cortical subnetworks support fast human swallowing.Communications biology · 2026Article
- Social Dysfunction in ADHD Children Associated With Increased Amygdala Functional Connectivity Instability: A Static and Dynamic Functional Connectivity Study.CNS neuroscience & therapeutics · 2026Article
- Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine-related dysfunction on tau and its impact on cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Charting higher-order models of brain function beyond pairwise interactions.Nature communications · 2026Article
- Neural manifold connectomics reveals multiregime functional connectivity.bioRxiv : the preprint server for biology · 2026Article
- Blunted modulation of hierarchical brain organization in opioid use disorder.Research square · 2026Article
- When Can Brain Connectivity Track the Working Mind? A Large-Scale Benchmark of Dynamic Functional Connectivity Across Cognitive Paradigms.bioRxiv : the preprint server for biology · 2026Article
- Review
- HESREN: A Derivative-Informed Reservoir Framework for Detecting Transient Neural Events and Windowless Estimation of Dynamic Functional Connectivity.Neuroinformatics · 2026Article
- Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026Review
196 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human brain integrates diverse cognitive processes into a coherent whole, shifting fluidly as a function of changing environmental demands. Despite recent progress, the neurobiological mechanisms responsible for this dynamic system-level integration remain poorly understood. Here we investigated the spatial, dynamic, and molecular signatures of system-wide neural activity across a range of cognitive tasks. We found that neuronal activity converged onto a low-dimensional manifold that facilitates the execution of diverse task states. Flow within this attractor space was associated with dissociable cognitive functions, unique patterns of network-level topology, and individual differences in fluid intelligence. The axes of the low-dimensional neurocognitive architecture aligned with regional differences in the density of neuromodulatory receptors, which in turn relate to distinct signatures of network controllability estimated from the structural connectome. These results advance our understanding of functional brain organization by emphasizing the interface between neural activity, neuromodulatory systems, and cognitive function.
Indexed as
Identifiers
30664771What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.