ArticleNature neuroscience2019
Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection.
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Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 52 papers, 1 of them a synthesis that pooled it.
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52citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
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52 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
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- Novel role of NCoR1 in impairing spatial memory through the mediation of a novel interacting protein DEC2.Cellular and molecular life sciences : CMLS · 2024Article
- Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model.bioRxiv : the preprint server for biology · 2024Article
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Corrections and comments
- Erratum issued
Authors and funding
25 authors at 6 institutions in 5 countries.
Wenjun ZhouDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA.
Yanlin HeUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5471-9016
Atteeq U RehmanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Yan KongDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA.
Sungguan HongDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA.
Guolian DingDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA.
Hari Krishna YalamanchiliDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Ying-Wooi WanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Basil PaulDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Chuhan WangDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA.
Yingyun GongDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA.
Wenxian ZhouDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Hao LiuDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
John DeanClinical Genetics Service, NHS Grampian, Aberdeen, Scotland, UK.
Emmanuel ScalaisPediatric Neurology, Centre Hospitalier de, Luxembourg, Luxembourg.
Mary O'DriscollWest Midlands Regional Clinical Genetics Service and Birmingham Health Partners, Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK.
Jenny E V MortonWest Midlands Regional Clinical Genetics Service and Birmingham Health Partners, Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK.
DDD study
Xinguo HouDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, China.
Qi WuUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Qingchun TongCenter for Metabolic and Degenerative Disease, Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-4561-2540
Zhandong LiuJan and Dan Duncan Neurological Research Institute, Department of Pediatrics, Texas Children's Hospital, Houston, TX, USA.
Pengfei LiuDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. pengfeil@bcm.edu.ORCID http://orcid.org/0000-0002-4177-709X
Yong XuUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. yongx@bcm.edu.ORCID http://orcid.org/0000-0002-4908-1572
Zheng SunDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA. zheng.sun@bcm.edu.ORCID http://orcid.org/0000-0002-6858-0633
Baylor College of Medicine · USBirmingham Women’s and Children’s NHS Foundation Trust · GBCentre Hospitalier de Luxembourg · LUChildren's Nutrition Research Center at Baylor College of Medicine · USNeurological Research Institute · USNHS Grampian · GB
Funding
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3MCRSPR II Supplement: Consortium for the production and cryopreservation of knockout miceU42OD011174 · OD · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L. · 2012 to 2015
$17.7MProject 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythmsP01DK113954 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI O'MALLEY, BERT W · 2018 to 2022
$7.9MSteps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, SAMACO, RODNEY C · 2014 to 2019
$7.8MGender-Specific Effects of Arsenic in DiabetesR01ES027544 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2021
$2.2MEpigenomic Remodeling of Metabolism by Exercise through AP-1R01DK111436 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2020
$2.0MHypothalamic Grb10 and body weightR01DK115761 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FRAZER, ALAN, XU, YONG · 2018 to 2021
$2.0MNeurobiology for the sex differences in energy balanceR01DK117281 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2018 to 2022
$1.8MA Novel AgRP Neurons to the Dorsal Raphe Circuit in Control of Energy ExpenditureR01DK109194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WU, QI · 2017 to 2021
$1.8MTargeting hypothalamic steroid receptor co-activator-1 to treat obesityR01DK101379 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2014 to 2017
$1.2MDe facto Target of Histone Deacetylase InhibitorsR21CA215591 · NCI · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2018
$345kA Novel AgRP Neurons to the Dorsal Raphe Circuit in Control of Energy ExpenditureR56DK109194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WU, QI · 2016 to 2016
$105kNCI NIH HHS R21 CA215591NICHD NIH HHS U54 HD083092NIDDK NIH HHS P01 DK113954NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK101379NIDDK NIH HHS R01 DK109194NIDDK NIH HHS R01 DK111436NIDDK NIH HHS R01 DK115761NIDDK NIH HHS R01 DK117281NIDDK NIH HHS R56 DK109194NIEHS NIH HHS R01 ES027544NIH HHS U42 OD011174Wellcome Trust
Abstract
Nuclear receptor corepressor 1 (NCOR1) and NCOR2 (also known as SMRT) regulate gene expression by activating histone deacetylase 3 through their deacetylase activation domain (DAD). We show that mice with DAD knock-in mutations have memory deficits, reduced anxiety levels, and reduced social interactions. Mice with NCOR1 and NORC2 depletion specifically in GABAergic neurons (NS-V mice) recapitulated the memory deficits and had reduced GABA
Indexed as
AnimalsCA3 Region, HippocampalDatabases, FactualExcitatory Postsynaptic PotentialsGABAergic NeuronsHypothalamusIntellectual DisabilityMemoryMemory DisordersMiceMice, TransgenicNeural PathwaysNeuronal PlasticityNuclear Receptor Co-Repressor 1Nuclear Receptor Co-Repressor 2Receptors, GABA-ANcor1 protein, mouseNcor2 protein, mouseNuclear Receptor Co-Repressor 1Nuclear Receptor Co-Repressor 2Receptors, GABA-A
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.