ArticleNature immunology2019
Memory CD4
Open access · bronzeAbstract read
In one paragraph
Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
100 citing papers in PubMed, 198 citations in OpenAlex.
- Extremely Preterm Infants Have Significant Alterations in Their Conventional T Cell Compartment during the First Weeks of Life.Journal of immunology (Baltimore, Md. : 1950) · 2020Trial
- Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth.Journal of immunology (Baltimore, Md. : 1950) · 2019Trial
- Immune development in early life.Nature immunology · 2026Review
- Underexplored maternal microbiomes: immune, metabolic, and microbial pathways shaping pregnancy outcomes.Infection and immunity · 2026Review
- A mother's touch: microbial guardians of early immune imprinting.Trends in immunology · 2026Review
- Microbiota-mediated mechanisms of mucosal immunity across the lifespan.Nature immunology · 2025Review
- A single-cell atlas of mouse central nervous system immune cells reveals unique infection-stage immune signatures during the progression of meningitis caused by Streptococcus suis.Communications biology · 2025Article
- Epigenetic instability and hypofunctionality of fetal Tregs allow a permissive regulatory environment for T effector memory maturation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age.Mucosal immunology · 2025Review
- Article
- The maternal-fetal interface at single-cell resolution: uncovering the cellular anatomy of the placenta and decidua.American journal of obstetrics and gynecology · 2025Review
- Microbiota-derived HNature communications · 2025Article
- Shaping immunity: the influence of the maternal gut bacteria on fetal immune development.Seminars in immunopathology · 2025Review
- No microorganism was detected in amniotic fluid of healthy pregnancies from the second trimester to the delivery.Microbiome · 2025Article
- Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq.Frontiers in immunology · 2025Article
- Decoding thymic development: a single-cell atlas of tree shrew immunity.Frontiers in immunology · 2025Article
- Naturally arising memory-phenotype CD4Science advances · 2024Article
- Article
- Transient PU.1 low fetal progenitors generate lymphoid progeny that contribute to adult immunity.Life science alliance · 2024Article
- Single-cell atlas of the small intestine throughout the human lifespan demonstrates unique features of fetal immune cells.Mucosal immunology · 2024Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 4 countries.
Na LiDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-5380-8554
Vincent van UnenDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-9339-8430
Tamim AbdelaalLeiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands.
Nannan GuoDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Sofya A KasatskayaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Kristin LadellDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.ORCID http://orcid.org/0000-0002-9856-2938
James E McLarenDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Evgeny S EgorovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Mark IzraelsonShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Susana M Chuva de Sousa LopesDepartment of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-3866-2803
Thomas HölltLeiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands.
Olga V BritanovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Jeroen EggermontDepartment of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Noel F C C de MirandaDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Dmitriy M ChudakovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.ORCID http://orcid.org/0000-0001-9416-2737
Boudewijn P F LelieveldtDepartment of Pattern Recognition and Bioinformatics Group, Delft University of Technology, Delft, the Netherlands.
Frits KoningDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands. F.Koning@lumc.nl.ORCID http://orcid.org/0000-0002-4007-5715
Leiden University Medical Center · NLCardiff University · GBInstitute of Bioorganic Chemistry · RUPrivolzhsky Research Medical University · RUSkolkovo Institute of Science and Technology · RU
Funding
Wellcome Trust
Abstract
The fetus is thought to be protected from exposure to foreign antigens, yet CD45RO
Indexed as
Antigen-Presenting CellsCD4-Positive T-LymphocytesCD5 AntigensCells, CulturedFetusFlow CytometryGene Expression ProfilingGene Expression Regulation, DevelopmentalHigh-Throughput Nucleotide SequencingHumansImmunologic MemoryImmunophenotypingIntestinesKi-67 AntigenCD5 AntigensKi-67 Antigen
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.