ArticleNature materials2019
Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway.
Article in Nature materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- A novel microporous biomaterial vaccine platform for long-lasting antibody mediated immunity against viral infection.Journal of controlled release : official journal of the Controlled Release Society · 2024Article
- Implanting mechanically reprogrammed fibroblasts for aged tissue regeneration and wound healing.Aging cell · 2024Article
- Interaction pathways of implant metal localized corrosion and macrophage inflammatory reactions.Bioactive materials · 2024Article
- Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues.Bioactive materials · 2023Article
- Initiation of type 2 immunity at barrier surfaces.Mucosal immunology · 2023Review
- Review
- Maternal IL-33 critically regulates tissue remodeling and type 2 immune responses in the uterus during early pregnancy in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering ACell reports · 2022Article
- Host type 2 immune response to xenogeneic serum components impairs biomaterial-directed osteo-regenerative therapies.Biomaterials · 2022Article
- Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis.Current osteoporosis reports · 2022Review
- The Possible Role of Bruton Tyrosine Kinase Inhibitors in the Treatment of COVID-19: A Review.Current therapeutic research, clinical and experimental · 2022Review
- The Paradigm Change of IL-33 in Vascular Biology.International journal of molecular sciences · 2021Review
- The Effects of Macrophage Phenotype on Osteogenic Differentiation of MSCs in the Presence of Polyethylene Particles.Biomedicines · 2021Article
- Early Events Triggering the Initiation of a Type 2 Immune Response.Trends in immunology · 2021Review
- Inhalant Mammal-Derived Lipocalin Allergens and the Innate Immunity.Frontiers in allergy · 2021Review
- Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin.Frontiers in immunology · 2021Article
- Reparative and Maladaptive Inflammation in Tendon Healing.Frontiers in bioengineering and biotechnology · 2021Review
- Heterogeneity in the initiation, development and function of type 2 immunity.Nature reviews. Immunology · 2020Review
- Induction of sterile type 2 inflammation.Nature materials · 2019Article
- The Regulatory Effects of Interleukin-4 Receptor Signaling on Neutrophils in Type 2 Immune Responses.Frontiers in immunology · 2019Review
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15 authors at 5 institutions in 1 country.
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Abstract
Initiation of the innate sterile inflammatory response that can develop in response to microparticle exposure is little understood. Here, we report that a potent type 2 immune response associated with the accumulation of neutrophils, eosinophils and alternatively activated (M2) macrophages was observed in response to sterile microparticles similar in size to wear debris associated with prosthetic implants. Although elevations in interleukin-33 (IL-33) and type 2 cytokines occurred independently of caspase-1 inflammasome signalling, the response was dependent on Bruton's tyrosine kinase (BTK). IL-33 was produced by macrophages and BTK-dependent expression of IL-33 by macrophages was sufficient to initiate the type 2 response. Analysis of inflammation in patient periprosthetic tissue also revealed type 2 responses under aseptic conditions in patients undergoing revision surgery. These findings indicate that microparticle-induced sterile inflammation is initiated by macrophages activated to produce IL-33. They further suggest that both BTK and IL-33 may provide therapeutic targets for wear debris-induced periprosthetic inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.