Evidence map›Paper›PMID 30664650›Full record

ArticleNature communications2019

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation.

Antoine Campagne, Ming-Kang Lee, Dina Zielinski, Audrey Michaud, Stéphanie Le Corre, Florent Dingli, Hong Chen, Lara Z Shahidian, Ivaylo Vassilev, Nicolas Servant and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.

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  20. Loss of histone deubiquitinase Bap1 triggers anti-tumor immunity.Cellular oncology (Dordrecht, Netherlands) · 2025
    Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Antoine CampagneInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France.
Ming-Kang LeeInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France.
Dina ZielinskiInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France.
Audrey MichaudInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France.
Stéphanie Le CorreInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France.
Florent DingliInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France.
Hong ChenInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France.
Lara Z ShahidianInstitute of Functional Epigenetics, Helmholtz Zentrum München, Neuherberg, 85764, Germany.
Ivaylo VassilevInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France.
Nicolas ServantInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France.
Damarys LoewInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France.
Eric PasmantDepartment of Molecular Genetics Pathology, Cochin Hospital, HUPC AP-HP, EA7331, Faculty of Pharmacy, University of Paris Descartes, Paris, 75014, France.
Sophie Postel-VinayDépartement d'Innovation Thérapeutique et Essais Précoces, INSERM U981, Gustave Roussy, Université Paris-Saclay, Villejuif, F-94805, France.
Michel WassefInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France. michel.wassef@curie.fr.
Raphaël MargueronInstitut Curie, Paris Sciences et Lettres Research University, Sorbonne University, 75005, Paris, France. raphael.margueron@curie.fr.
Centre National de la Recherche Scientifique · FRInserm · FRUniversité Paris Sciences et Lettres · FRDélégation Paris 5 · FRHelmholtz Zentrum München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Drosophila, a complex consisting of Calypso and ASX catalyzes H2A deubiquitination and has been reported to act as part of the Polycomb machinery in transcriptional silencing. The mammalian homologs of these proteins (BAP1 and ASXL1/2/3, respectively), are frequently mutated in various cancer types, yet their precise functions remain unclear. Using an integrative approach based on isogenic cell lines generated with CRISPR/Cas9, we uncover an unanticipated role for BAP1 in gene activation. This function requires the assembly of an enzymatically active BAP1-associated core complex (BAP1.com) containing one of the redundant ASXL proteins. We investigate the mechanism underlying BAP1.com-mediated transcriptional regulation and show that it does not participate in Polycomb-mediated silencing. Instead, our results establish that the function of BAP1.com is to safeguard transcriptionally active genes against silencing by the Polycomb Repressive Complex 1.

Indexed as

Protein Processing, Post-TranslationalAnimalsB-LymphocytesCell Cycle ProteinsCell Line, TumorCRISPR-Cas SystemsDrosophila melanogasterGene EditingHaploidyHeLa CellsHistonesHumansPolycomb Repressive Complex 1Repressor ProteinsSf9 CellsSpodopteraASXL1 protein, humanASXL2 protein, humanASXL3 protein, humanBAP1 protein, humanCell Cycle ProteinsHistonesPolycomb Repressive Complex 1PRC1 protein, humanRepressor ProteinsTranscription FactorsTumor Suppressor ProteinsUbiquitin Thiolesterase

Identifiers

PMID30664650
PMCPMC6341105
OpenAlexW2911057728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.