Evidence map›Paper›PMID 30664638›Full record

ArticleNature communications2019

Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma.

Kim Wong, Louise van der Weyden, Courtney R Schott, Alastair Foote, Fernando Constantino-Casas, Sionagh Smith, Jane M Dobson, Elizabeth P Murchison, Hong Wu, Iwei Yeh and 13 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Review
  12. Transcriptomic profiling of a canine malignant eyelid melanoma.Brazilian journal of veterinary medicine · 2026
    Article
  13. Review
  14. Article
  15. Ancestry and somatic profile predict acral melanoma origin and prognosis.medRxiv : the preprint server for health sciences · 2025
    Article
  16. Article
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  18. Article
  19. Article
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Kim WongWellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.ORCID http://orcid.org/0000-0002-0984-1477
Louise van der WeydenWellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Courtney R SchottDepartment of Pathobiology, University of Guelph, 50 Stone Road E., Guelph, ON, N1G 2W1, Canada.
Alastair FooteRossdales Equine Hospital and Diagnostic Centre, High Street, Newmarket, Suffolk, CB8 8JS, UK.
Fernando Constantino-CasasDepartment of Veterinary Medicine, Cambridge Veterinary School, University of Cambridge, Cambridge, CB3 0ES, UK.
Sionagh SmithThe Royal (Dick) School of Veterinary Studies and The Roslin Institute, Easter Bush Campus, Midlothian, EH25 9RG, UK.
Jane M DobsonDepartment of Veterinary Medicine, Cambridge Veterinary School, University of Cambridge, Cambridge, CB3 0ES, UK.
Elizabeth P MurchisonDepartment of Veterinary Medicine, Cambridge Veterinary School, University of Cambridge, Cambridge, CB3 0ES, UK.ORCID http://orcid.org/0000-0001-7462-8907
Hong WuDepartments of Dermatology and Pathology, University of California, San Francisco, CA, 94143, USA.
Iwei YehDepartments of Dermatology and Pathology, University of California, San Francisco, CA, 94143, USA.
Douglas R FullenDepartments of Pathology and Dermatology, University of Michigan Medical School, 3261 Medical Science I, 1301 Catherine, Ann Arbor, MI, 48109-5602, USA.
Nancy JosephDepartments of Dermatology and Pathology, University of California, San Francisco, CA, 94143, USA.
Boris C BastianDepartments of Dermatology and Pathology, University of California, San Francisco, CA, 94143, USA.
Rajiv M PatelDepartments of Pathology and Dermatology, University of Michigan Medical School, 3261 Medical Science I, 1301 Catherine, Ann Arbor, MI, 48109-5602, USA.
Inigo MartincorenaWellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Carla Daniela Robles-EspinozaWellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Vivek IyerWellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Marieke L KuijjerDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA.
Mark J ArendsUniversity of Edinburgh, Division of Pathology, Centre for Comparative Pathology, Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, UK.
Thomas BrennWellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Paul W HarmsDepartments of Pathology and Dermatology, University of Michigan Medical School, 3261 Medical Science I, 1301 Catherine, Ann Arbor, MI, 48109-5602, USA.
Geoffrey A WoodDepartment of Pathobiology, University of Guelph, 50 Stone Road E., Guelph, ON, N1G 2W1, Canada.ORCID http://orcid.org/0000-0003-1756-8607
David J AdamsWellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. da1@sanger.ac.uk.

Funding

Cancer Research UK 21717Cancer Research UK 21777Medical Research Council MR/S01473X/1Wellcome Trust
6 · The paper itself

Abstract

Mucosal melanoma is a rare and poorly characterized subtype of human melanoma. Here we perform a cross-species analysis by sequencing tumor-germline pairs from 46 primary human muscosal, 65 primary canine oral and 28 primary equine melanoma cases from mucosal sites. Analysis of these data reveals recurrently mutated driver genes shared between species such as NRAS, FAT4, PTPRJ, TP53 and PTEN, and pathogenic germline alleles of BRCA1, BRCA2 and TP53. We identify a UV mutation signature in a small number of samples, including human cases from the lip and nasal mucosa. A cross-species comparative analysis of recurrent copy number alterations identifies several candidate drivers including MDM2, B2M, KNSTRN and BUB1B. Comparison of somatic mutations in recurrences and metastases to those in the primary tumor suggests pervasive intra-tumor heterogeneity. Collectively, these studies suggest a convergence of some genetic changes in mucosal melanomas between species but also distinctly different paths to tumorigenesis.

Indexed as

Gene Expression Regulation, NeoplasticGerm-Line MutationAnimalsBRCA1 ProteinBRCA2 ProteinCadherinsCarcinogenesisCell Cycle ProteinsDNA Copy Number VariationsDogsGTP PhosphohydrolasesHorsesHumansMelanomaMembrane ProteinsMicrotubule-Associated ProteinsBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanBUB1B protein, humanCadherinsCell Cycle ProteinsFAT4 protein, humanGTP PhosphohydrolasesKNSTRN protein, humanMDM2 protein, humanMembrane ProteinsMicrotubule-Associated ProteinsNeoplasm ProteinsNRAS protein, humanProtein Serine-Threonine KinasesProto-Oncogene Proteins c-mdm2PTEN PhosphohydrolasePTEN protein, humanPTPRJ protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 3TP53 protein, humanTumor Suppressor Protein p53Tumor Suppressor Proteins

Identifiers

PMID30664638
PMCPMC6341101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.