Evidence map›Paper›PMID 30664625›Full record

ArticleTranslational psychiatry2019

Constitutional mislocalization of Pten drives precocious maturation in oligodendrocytes and aberrant myelination in model of autism spectrum disorder.

Hyunpil Lee, Stetson Thacker, Nicholas Sarn, Ranjan Dutta, Charis Eng

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
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  8. Functional myelin in cognition and neurodevelopmental disorders.Cellular and molecular life sciences : CMLS · 2024
    Review
  9. Review
  10. Conditional Deletion ofInternational journal of molecular sciences · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hyunpil LeeGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, USA.
Stetson ThackerGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, USA.ORCID http://orcid.org/0000-0001-6050-409X
Nicholas SarnGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, USA.
Ranjan DuttaCleveland Clinic Lerner College of Medicine, Cleveland, OH, 44195, USA.ORCID http://orcid.org/0000-0001-8502-4455
Charis EngGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, USA. engc@ccf.org.ORCID http://orcid.org/0000-0002-3693-5145
Cleveland Clinic Lerner College of Medicine · US

Funding

MicroRNAs as critical regulators of remyelination in Multiple SclerosisR01NS096148 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI DUTTA, RANJAN · 2016 to 2020
$1.7M
Molecular Medicine Training ProgramT32GM088088 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI SMITH, JONATHAN D · 2011 to 2020
$1.7M
NIGMS NIH HHS T32 GM088088NINDS NIH HHS R01 NS096148
6 · The paper itself

Abstract

There is a strong genetic association between germline PTEN mutation and autism spectrum disorder (ASD), making Pten-mutant models exemplary for the study of ASD pathophysiology. We developed the Pten

Indexed as

AnimalsAutism Spectrum DisorderBrainCell DifferentiationCells, CulturedDisease Models, AnimalFemaleMaleMiceMutation, MissenseMyelin ProteinsNeurogenesisNeurogliaOligodendrocyte Precursor CellsPTEN PhosphohydrolaseMyelin ProteinsPTEN PhosphohydrolasePten protein, mouse

Identifiers

PMID30664625
PMCPMC6341090
OpenAlexW2908707306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.