Evidence map›Paper›PMID 30664620›Full record

ArticleTranslational psychiatry2019

Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression.

Alexander Kautzky, Gregory M James, Cecile Philippe, Pia Baldinger-Melich, Christoph Kraus, Georg S Kranz, Thomas Vanicek, Gregor Gryglewski, Annette M Hartmann, Andreas Hahn and 5 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Alexander KautzkyDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria.
Gregory M JamesDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria.
Cecile PhilippeDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Wien, Austria.
Pia Baldinger-MelichDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria.
Christoph KrausDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria.
Georg S KranzDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria.ORCID http://orcid.org/0000-0002-3892-1804
Thomas VanicekDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria.
Gregor GryglewskiDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria.
Annette M HartmannUniversity Clinic for Psychiatry, Psychotherapy and Psychosomatic, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Andreas HahnDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria.
Wolfgang WadsakDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Wien, Austria.ORCID http://orcid.org/0000-0003-4479-8053
Markus MitterhauserDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Wien, Austria.
Dan RujescuUniversity Clinic for Psychiatry, Psychotherapy and Psychosomatic, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Siegfried KasperDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria.
Rupert LanzenbergerDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria. rupert.lanzenberger@meduniwien.ac.at.
Medical University of Vienna · ATMartin Luther University Halle-Wittenberg · DECenter For Biomarker Research In Medicine · ATLudwig Boltzmann Institute Applied Diagnostics · AT

Funding

Austrian Science Fund FWF KLI 551
6 · The paper itself

Abstract

Alterations of the 5-HT

Indexed as

Epistasis, GeneticAdultAllelesBrainBrain-Derived Neurotrophic FactorCross-Sectional StudiesDepressive DisorderFemaleGenotypeHealthy VolunteersHumansMaleMiddle AgedPiperazinesPolymorphism, Single NucleotidePositron-Emission TomographyBDNF protein, humanBrain-Derived Neurotrophic FactorHTR1A protein, humanN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamidePiperazinesPyridinesReceptor, Serotonin, 5-HT1A

Identifiers

PMID30664620
PMCPMC6341100
OpenAlexW2921484000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.