Evidence map›Paper›PMID 30664590›Full record

ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2019

Development of the Pediatric Extracorporeal Membrane Oxygenation Prediction Model for Risk-Adjusting Mortality.

David K Bailly, Ron W Reeder, Melissa Winder, Ryan P Barbaro, Murray M Pollack, Frank W Moler, Kathleen L Meert, Robert A Berg, Joseph Carcillo, Athena F Zuppa and 13 more

Abstract readMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

David K BaillyDivision of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, UT.
Ron W ReederDivision of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, UT.
Melissa WinderDepartment of Pediatric Critical Care, Primary Children's Hospital, Salt Lake City, UT.
Ryan P BarbaroDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Murray M PollackDepartment of Pediatrics, Children's National Medical Center, Washington, DC.
Frank W MolerDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Kathleen L MeertDepartment of Pediatrics, Children's Hospital of Michigan, Detroit, MI.
Robert A BergDepartment of Anesthesia and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA.
Joseph CarcilloDepartment of Critical Care Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA.
Athena F ZuppaDepartment of Anesthesia and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA.
Christopher NewthDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, CA.
John BergerDepartment of Pediatrics, Children's National Medical Center, Washington, DC.
Michael J BellDepartment of Critical Care Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA.
Michael J DeanDivision of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, UT.
Carol NicholsonTrauma and Critical Illness Branch, National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD.
Pamela Garcia-FilionDepartment of Biomedical Informatics, Phoenix Children's Hospital, Phoenix, AZ.
David WesselDepartment of Pediatrics, Children's National Medical Center, Washington, DC.
Sabrina HeidemannDepartment of Pediatrics, Children's Hospital of Michigan, Detroit, MI.
Allan DoctorDepartments of Pediatrics and Biochemistry, Washington University, St. Louis, MO.
Rick HarrisonDepartment of Pediatrics, Mattel Children's Hospital UCLA, Los Angeles, CA.
Susan L BrattonDivision of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, UT.
Heidi DaltonDepartment of Pediatrics, Inova Fairfax Hospital, Fall Church, VA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN)

Funding

Data Coordinating Center for the Collaborative Pediatric Critical Care Research NetworkU01HD049934 · NICHD · UNIVERSITY OF UTAH · PI DEAN, JONATHAN MICHAEL · 2005 to 2020
$35.2M
Physiologically Guided Ventilator Strategies in ChildrenU10HD050012 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI NEWTH, CHRISTOPHER JOHN · 2005 to 2014
$3.7M
Neurodevelopmental Outcome after Cardiac Intensive CareU10HD049981 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WESSEL, DAVID LLOYD · 2005 to 2014
$3.7M
Collaborative Pediatric Critical Care Research NetworkU10HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2005 to 2014
$3.2M
Metoclopramide prevents PICU nosocomial infectionU10HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2005 to 2014
$3.1M
Collaborative Pediatric Critical Care Research Network (CPCCRN) at Children's NationalUG1HD049981 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI POLLACK, MURRAY MICHAEL, WESSEL, DAVID LLOYD · 2015 to 2020
$1.8M
Renewal Application for the Childrens Hospital of Pittsburgh Collaborative Pediatric Critical Care Research Network SiteUG1HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2015 to 2020
$1.6M
Collaborative Pediatric Critical Care Research NetworkUG1HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2015 to 2020
$1.6M
Pediatric Critical Care Research Network at Children's Hospital of PhiladelphiaU10HD063108 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN · 2010 to 2014
$1.4M
Predicting Morbidity from Pediatric Critical CareU10HD063114 · NICHD · PHOENIX CHILDREN'S HOSPITAL · PI DALTON, HEIDI J, LUND, DENNIS P · 2010 to 2014
$1.4M
Collaborative Pediatric Critical Care Research Network - Clinical SiteRL1HD107773 · NICHD · CENTRAL MICHIGAN UNIVERSITY · PI KATHLEEN L. MEERT · 2021 to 2026
$862k
NICHD NIH HHS L40 HD081676NICHD NIH HHS RL1 HD107773NICHD NIH HHS U01 HD049934NICHD NIH HHS U10 HD049981NICHD NIH HHS U10 HD049983NICHD NIH HHS U10 HD050012NICHD NIH HHS U10 HD050096NICHD NIH HHS U10 HD063108NICHD NIH HHS U10 HD063114NICHD NIH HHS UG1 HD049981NICHD NIH HHS UG1 HD049983NICHD NIH HHS UG1 HD050096
6 · The paper itself

Abstract

objectivesTo develop a prognostic model for predicting mortality at time of extracorporeal membrane oxygenation initiation for children which is important for determining center-specific risk-adjusted outcomes.

designMultivariable logistic regression using a large national cohort of pediatric extracorporeal membrane oxygenation patients.

settingThe ICUs of the eight tertiary care children's hospitals of the Collaborative Pediatric Critical Care Research Network. PATIENTS: Five-hundred fourteen children (< 19 yr old), enrolled with an initial extracorporeal membrane oxygenation run for any indication between January 2012 and September 2014.

interventionsNone. MEASUREMENTS AND MAIN

resultsA total of 514 first extracorporeal membrane oxygenation runs were analyzed with an overall mortality of 45% (n = 232). Weighted logistic regression was used for model selection and internal validation was performed using cross validation. The variables included in the Pediatric Extracorporeal Membrane Oxygenation Prediction model were age (pre-term neonate, full-term neonate, infant, child, and adolescent), indication for extracorporeal membrane oxygenation (extracorporeal cardiopulmonary resuscitation, cardiac, or respiratory), meconium aspiration, congenital diaphragmatic hernia, documented blood stream infection, arterial blood pH, partial thromboplastin time, and international normalized ratio. The highest risk of mortality was associated with the presence of a documented blood stream infection (odds ratio, 5.26; CI, 1.90-14.57) followed by extracorporeal cardiopulmonary resuscitation (odds ratio, 4.36; CI, 2.23-8.51). The C-statistic was 0.75 (95% CI, 0.70-0.80).

conclusionsThe Pediatric Extracorporeal Membrane Oxygenation Prediction model represents a model for predicting in-hospital mortality among children receiving extracorporeal membrane oxygenation support for any indication. Consequently, it holds promise as the first comprehensive pediatric extracorporeal membrane oxygenation risk stratification model which is important for benchmarking extracorporeal membrane oxygenation outcomes across many centers.

Indexed as

Hospital MortalityRisk AdjustmentAdolescentCase-Control StudiesChildChild, PreschoolExtracorporeal Membrane OxygenationFemaleHumansInfantInfant, NewbornIntensive Care Units, PediatricLogistic ModelsMaleOutcome Assessment, Health Care

Identifiers

PMID30664590
PMCPMC6502677

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