ArticleJournal of Alzheimer's disease : JAD2019
Reducing the Number of People with Dementia Through Primary Prevention in Mozambique, Brazil, and Portugal: An Analysis of Population-Based Data.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A critical systematic review of the impact of sedentarism and physical inactivity on the cognitive performance of children.Systematic reviews · 2026Pooled it
- Population attributable fractions of modifiable risk factors for dementia: a systematic review and meta-analysis.The lancet. Healthy longevity · 2024Pooled it
- Country-specific modifiable dementia risk factors across the Western Pacific Region determined by population attributable fraction.The Lancet regional health. Western Pacific · 2026Article
- Population attributable fraction of modifiable risk factors for dementia in the Democratic Republic of Congo: A community-based cross-sectional analysis.medRxiv : the preprint server for health sciences · 2026Article
- Construction of a classification model for dementia among Brazilian adults aged 50 and over.Frontiers in aging neuroscience · 2026Article
- Evaluating a dementia risk reduction training program for primary health care educators in Nigeria.NPJ dementia · 2026Article
- Personality traits as protective factors of dementia development.Dementia & neuropsychologia · 2024Article
- Monitoring risk factors for dementia in middle-aged and older adults: a longitudinal study.Dementia & neuropsychologia · 2024Article
- Have We Been Underestimating Modifiable Dementia Risk? An Alternative Approach for Calculating the Combined Population Attributable Fraction for Modifiable Dementia Risk Factors.American journal of epidemiology · 2023Article
- Ameliorative effect of carveol on scopolamine-induced memory impairment in rats.Iranian journal of basic medical sciences · 2022Article
- Subjective cognitive decline, mild cognitive impairment, and dementia - syndromic approach: recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology.Dementia & neuropsychologia · 2022Article
- Preventable risk factors of dementia: Population attributable fractions in a Brazilian population-based study.Lancet regional health. Americas · 2022Article
- Risk Factors Associated With Alzheimer Disease and Related Dementias by Sex and Race and Ethnicity in the US.JAMA neurology · 2022Article
- Population attributable fraction of modifiable risk factors for dementia in Chile.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- How Many People Live with Dementia in Portugal? A Discussion Paper of National Estimates.Portuguese journal of public health · 2021Article
- Dementia in Latin America: Paving the way toward a regional action plan.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Association between periodontitis and Alzheimer's disease and its impact on the self-perceived oral health status: a case-control study.Clinical oral investigations · 2021Article
- The Effect of Sex and Wealth on Population Attributable Risk Factors for Dementia in South Africa.Frontiers in neurology · 2021Article
- Dementia, Risk, Risk Reduction, and Translation into Practice: An International Research Network for Dementia Prevention (IRNDP) Special Issue.Journal of Alzheimer's disease : JAD · 2019Article
- Population-Based Approaches to Dementia Prevention.Journal of Alzheimer's disease : JAD · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundMost people with dementia live in low- and middle-income countries and little is known about the potential for reducing these numbers by reducing key risk factors.
objectiveTo investigate the potential for dementia incidence reduction in Brazil, Mozambique, and Portugal (a culturally related, high-income country).
methodsWe replicated previously published methods and based on the relative risks from previous studies, we estimated the population-attributable risk (PAR) of dementia in Mozambique, Brazil, and Portugal for seven modifiable risk factors associated with dementia (low educational attainment, physical inactivity, midlife hypertension, midlife obesity, depression, smoking, and diabetes mellitus). The combined PAR was calculated and adjusted for associations between risk factors. The potential for risk factor reduction was assessed by examining the effect of relative reductions of 10% and 20% per decade for each of the risk factors on projections for dementia cases for each decade until 2050.
resultsAfter adjusting for non-independence of risk factors, 24.4%, 32.3%, and 40.1% of dementia cases could be related to seven potentially modifiable risk factors in Mozambique, Brazil, and Portugal, respectively. Reducing the prevalence of each risk factor by 20% per decade could, by 2050, potentially reduce the prevalence of dementia in Mozambique, Brazil, and Portugal by 12.9%, 16.2%, and 19.5%, respectively.
conclusionThere is a substantial difference between the countries in the percentage of dementia cases that could be attributable to the seven potentially modifiable risk factors. The proportion of cases that could be prevented by 2050 if measures were taken to address these main risk factors was higher in Portugal than in Brazil and Mozambique. Each country or region should consider their unique risk factor profile when developing dementia risk reduction programs.
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