Evidence map›Paper›PMID 30663936›Full record

ArticleFly2018

Maintenance of Rhodopsin levels in Drosophila photoreceptor and phototransduction requires Protein Kinase D.

Sudipta Ashe, Shweta Yadav

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fly, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sudipta Ashea National Centre for Biological Sciences-TIFR, GKVK Campus, Bellary Road , Bangalore , 560065 , India.ORCID 0000-0002-7011-1078
Shweta Yadava National Centre for Biological Sciences-TIFR, GKVK Campus, Bellary Road , Bangalore , 560065 , India.ORCID 0000-0001-9760-3382
Manipal Academy of Higher Education · INNational Centre for Biological Sciences · IN

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537
6 · The paper itself

Abstract

During Drosophila phototransduction, the G protein coupled receptor (GPCR) Rhodopsin (Rh1) transduces photon absorption into electrical signal via G-protein coupled activation of phospholipase C (PLC). Rh1 levels in the plasma membrane are critical for normal sensitivity to light. In this study, we report that Protein Kinase D (dPKD) regulates Rh1 homeostasis in adult photoreceptors. Although eye development and retinal structure are unaffected in the dPKD hypomorph (dPKD

Indexed as

Light Signal TransductionAnimalsDrosophila melanogasterDrosophila ProteinsGene Expression RegulationPhotoreceptor Cells, InvertebrateProtein Kinase CRhodopsinDrosophila ProteinsProtein Kinase Cprotein kinase DRhodopsinelectroretinogram (ERG)phototransductionProtein Kinase Dretinal degenerationrhodopsinrhodopsin loaded vesicle (RLVs)

Identifiers

PMID30663936
PMCPMC6988883
OpenAlexW2913734947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.