Evidence map›Paper›PMID 30663929›Full record

ReviewTranscription2019

Balanced between order and disorder: a new phase in transcription elongation control and beyond.

Huasong Lu, Rongdiao Liu, Qiang Zhou

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Transcription, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Huasong Lua Department of Molecular and Cell Biology , University of California , Berkeley , CA , USA.
Rongdiao Liub School of Pharmaceutical Sciences , Xiamen University , Xiamen , Fujian , China.
Qiang Zhoua Department of Molecular and Cell Biology , University of California , Berkeley , CA , USA.
University of California, Berkeley · USXiamen University · CN

Funding

REGULATION OF TRANSCRIPTIONAL ELONGATION BY HIV1 TATR01AI041757 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZHOU, QIANG · 1997 to 2019
$6.6M
NIAID NIH HHS R01 AI041757
6 · The paper itself

Abstract

We recently reported that the cyclin T1 histidine-rich domain creates a phase-separated environment to promote hyperphosphorylation of RNA polymerase II C-terminal domain and robust transcriptional elongation by P-TEFb. Here, we discuss this and several other recent discoveries to demonstrate that phase separation is important for controlling various aspects of transcription.

Indexed as

Cyclin THistidineHumansPhosphorylationPositive Transcriptional Elongation Factor BRNA Polymerase IITranscription, GeneticCyclin THistidinePositive Transcriptional Elongation Factor BRNA Polymerase IIPhase separationP-TEFbRNA polymerase II CTDtranscriptional controltranscription elongation

Identifiers

PMID30663929
PMCPMC6602568
OpenAlexW2914852787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.