Evidence map›Paper›PMID 30663848›Full record

ArticleJournal of thrombosis and haemostasis : JTH2019

Loss of fibrinogen in zebrafish results in an asymptomatic embryonic hemostatic defect and synthetic lethality with thrombocytopenia.

Zhilian Hu, Kari I Lavik, Yang Liu, Andy H Vo, Catherine E Richter, Jorge Di Paola, Jordan A Shavit

Open access · greenAbstract read
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  7. Fishing for answers to hemostatic and thrombotic disease: Genome editing in zebrafish.Research and practice in thrombosis and haemostasis · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Zhilian HuDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Kari I LavikDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Yang LiuDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Andy H VoDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Catherine E RichterDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Jorge Di PaolaDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
Jordan A ShavitDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USUniversity of Chicago · USUniversity of Colorado Denver · US

Funding

Training Program in Molecular HematologyT32HL007622 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUNG WON CHOI, Jordan A. Shavit · 1986 to 2026
$9.2M
A Systems Biology Approach to Predicting Bleeding in HemophiliaR01HL120728 · NHLBI · COLORADO SCHOOL OF MINES · PI DI PAOLA, JORGE A, FOGELSON, AARON L · 2014 to 2018
$2.7M
Dissecting the Genetics of Human Hemostatic Disorders Using ZebrafishR01HL124232 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAVIT, JORDAN A · 2015 to 2019
$1.9M
Identification of novel therapeutics for hemostatic disorders using zebrafishR01HL125774 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAVIT, JORDAN A · 2018 to 2020
$899k
NHLBI NIH HHS R01 HL120728NHLBI NIH HHS R01 HL124232NHLBI NIH HHS R01 HL125774NHLBI NIH HHS T32 HL007622
6 · The paper itself

Abstract

Essentials Loss of fibrinogen in zebrafish has been previously shown to result in adult onset hemorrhage Hemostatic defects were discovered in early fga

Indexed as

HemostasisAfibrinogenemiaAnimalsAnimals, Genetically ModifiedFibrinogenHemorrhageHumansNF-E2 Transcription Factor, p45 SubunitSynthetic Lethal MutationsThrombocytopeniaZebrafishZebrafish ProteinsFGA protein, humanFibrinogennfe2 protein, zebrafishNF-E2 Transcription Factor, p45 SubunitZebrafish Proteinsfibrinogengenome editinghemostasisthrombocytopeniazebrafish

Identifiers

PMID30663848
PMCPMC6443434
OpenAlexW2914538413

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.