Evidence map›Paper›PMID 30663832›Full record

ArticleChembiochem : a European journal of chemical biology2019

Synthetic and Crystallographic Insight into Exploiting sp

Travis Coyle, Liang Wu, Aleksandra W Debowski, Gideon J Davies, Keith A Stubbs

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Synthetic and Crystallographic Insight into Exploiting spChembiochem : a European journal of chemical biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Travis CoyleSchool of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
Liang WuDepartment of Chemistry, York Structural Laboratory, University of York, Heslington, York, YO10 5DD, UK.
Aleksandra W DebowskiSchool of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
Gideon J DaviesDepartment of Chemistry, York Structural Laboratory, University of York, Heslington, York, YO10 5DD, UK.
Keith A StubbsSchool of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.ORCID 0000-0001-6899-402X
The University of Western Australia · AUUniversity of York · GBUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, α-l-fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel α-l-fucosidase inhibitors, with X-ray crystallographic analysis using an α-l-fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class.

Indexed as

Glycoside Hydrolase Inhibitorsalpha-L-FucosidaseBacteroides thetaiotaomicronCrystallography, X-RayFucosealpha-L-FucosidaseFucoseGlycoside Hydrolase Inhibitorscarbamateenzyme inhibitorsfucosidasesglycosidases0hydroximolactone

Identifiers

PMID30663832
PMCPMC6589914
OpenAlexW2914332584

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.