ArticleSubstance use & misuse2019
Genetic and Environmental Risk Factors for Cannabis Use: Preliminary Results for the Role of Parental Care Perception.
Article in Substance use & misuse, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Negative Urgency Mediates the Effect of Family Conflict on Cannabis Positive Expectancy: The Moderating Role of Anterior Cingulate Cortex.Addiction biology · 2026Article
- Intergenerational Transmission of Cannabis Use: Testing Genetic Risk and the Mitigating Influences of Parent Positive Behavior Support in Early Childhood.Research on child and adolescent psychopathology · 2025Article
- Cognitive Effects of Cannabis Use: A Comprehensive Review Across Domains.Neurology international · 2025Review
- Invited Expert Opinion- Bioinformatic and Limitation Directives to Help Adopt Genetic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Required Analytic Evidence to Induce Dopamine Homeostatsis.Medical research archives · 2023Article
- Supporting Machine Learning Model in the Treatment of Chronic Pain.Biomedicines · 2023Article
- Cannabis Pharmacogenomics: A Path to Personalized Medicine.Current issues in molecular biology · 2023Review
- Neurogenetic and Epigenetic Aspects of Cannabinoids.Epigenomes · 2022Article
- Hypothesizing in the Face of the Opioid Crisis Coupling Genetic Addiction Risk Severity (GARS) Testing with Electrotherapeutic Nonopioid Modalities Such as H-Wave Could Attenuate Both Pain and Hedonic Addictive Behaviors.International journal of environmental research and public health · 2022Article
- Pharmacogenetics of Addiction Therapy.Methods in molecular biology (Clifton, N.J.) · 2022Article
- 3-Year Follow-up of Lower Risk Cannabis Use Patterns: Evidence from a Longitudinal Survey.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022Article
- Understanding the genetics and neurobiological pathways behind addiction (Review).Experimental and therapeutic medicine · 2021Review
- In Search of Reward Deficiency Syndrome (RDS)-free Controls: The "Holy Grail" in Genetic Addiction Risk Testing.Current psychopharmacology · 2020Article
- Determining Risks for Cannabis Use Disorder in the Face of Changing Legal Policies.Current addiction reports · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundVulnerability to cannabis use (CU) initiation and problematic use have been shown to be affected by both genetic and environmental factors, with still inconclusive and uncertain evidence.
objectiveAim of the present study was to investigate the possible interplay between gene polymorphisms and psychosocial conditions in CU susceptibility.
methodsNinety-two cannabis users and ninety-three controls have been included in the study. Exclusion criteria were serious mental health disorders and severe somatic disorders, use of other drugs and alcohol abuse; control subjects were not screened to remove Reward Deficiency Syndrome (RDS) behaviors. A candidate gene association study was performed, including variants related to dopaminergic and endocannabinoids pathways. Adverse childhood experiences and quality of parental care have been retrospectively explored utilizing ACES (Adverse Children Experience Scale), CECA-q (Child Experience of Care and Abuse Questionnaire), PBI (Parental Bonding Instrument).
resultsOur findings evidenced a significant association between rs1800497 Taq1A of ANKK1 gene and CU. Parental care was found to be protective factor, with emotional and physical neglect specifically influencing CU. Gender also played a role in CU, with males smoking more than females. However, when tested together genotypes and psychosocial variables, the significance of observed genetic differences disappeared.
conclusionsOur results confirm a significant role of Taq1A polymorphism in CU vulnerability. A primary role of environmental factors in mediating genetic risk has been highlighted: parental care could be considered the main target to design early prevention programs and strategies.
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