Evidence map›Paper›PMID 30662935›Full record

ArticleAdvanced biosystems2017

Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling.

Shue Wang, Jian Sun, Yuan Xiao, Yi Lu, Donna D Zhang, Pak Kin Wong

Open access · greenAbstract read
In one paragraph

Article in Advanced biosystems, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. YAP/TAZ drives Notch and angiogenesis mechanoregulation in silico.NPJ systems biology and applications · 2024
    Article
  4. Type H vessels: functions in bone development and diseases.Frontiers in cell and developmental biology · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Born to Run? Diverse Modes of Epithelial Migration.Frontiers in cell and developmental biology · 2021
    Review
  11. Review
  12. Cell-Cell Mechanical Communication in Cancer.Cellular and molecular bioengineering · 2019
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shue WangDepartment of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ 85721 USA.
Jian SunDepartment of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ 85721 USA.
Yuan XiaoDepartment of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ 85721 USA Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802 USA.
Yi LuDepartment of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ 85721 USA Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802 USA.
Donna D ZhangDepartment of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85721 USA.
Pak Kin WongDepartment of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ 85721 USA Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802 USA.
University of Arizona · US

Funding

Mechanoregulation of Tissue MorphogenesisDP2OD007161 · OD · UNIVERSITY OF ARIZONA · PI WONG, PAK KIN · 2010 to 2010
$2.3M
NIH HHS DP2 OD007161
6 · The paper itself

Abstract

Mechanical force plays pivotal roles in vascular development during tissue growth and regeneration. Nevertheless, the process by which mechanical force controls the vascular architecture remains poorly understood. Using a systems bioengineering approach, we show that intercellular tension negatively regulates tip cell formation via Notch1-Dll4 signaling in mouse retinal angiogenesis in vivo, sprouting embryoid bodies, and human endothelial cell networks

Indexed as

angiogenesismechanoregulationnanoparticlesNotch signalingtip cells

Identifiers

PMID30662935
PMCPMC6338428
OpenAlexW2583158457

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.