ArticleAlzheimer's & dementia (New York, N. Y.)2018
Effects of sex, educational background, and chronic kidney disease grading on longitudinal cognitive and functional decline in patients in the Japanese Alzheimer's Disease Neuroimaging Initiative study.
Article in Alzheimer's & dementia (New York, N. Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex differences in Alzheimer's disease: a systematic review of two decades of neuroimaging research.The British journal of radiology · 2026Pooled it
- Changes in the Activities of Daily Living and Associated Factors of Older Adults After Home-Based Rehabilitation: A Multicenter Prospective 6-Month Follow-Up Study.Journal of general and family medicine · 2026Article
- Cognitive Impairment: A Novel Risk Factor for Rapid Kidney Function Decline and Incident CKD in Middle-Aged Adults.Kidney360 · 2025Article
- Uremic Toxins, CKD, and Cognitive Dysfunction.Journal of the American Society of Nephrology : JASN · 2025Review
- Gender-specific factors associated with the Japanese version of the trail making test among Japanese workers.Journal of physical therapy science · 2023Article
- Predictors of probable attention deficit hyperactivity disorder in elderly patients with mild cognitive impairment visiting a memory clinic.PCN reports : psychiatry and clinical neurosciences · 2023Article
- Estimation of Human Cerebral Atrophy Based on Systemic Metabolic Status Using Machine Learning.Frontiers in neurology · 2022Article
- Disentangling the Relationship Between Chronic Kidney Disease and Cognitive Disorders.Frontiers in neurology · 2022Review
- Article
- Gait speed, life-space mobility and mild cognitive impairment in patients with coronary artery disease.Heart and vessels · 2021Article
- Sex differences and the role of education in cognitive ageing: analysis of two UK-based prospective cohort studies.The Lancet. Public health · 2021Article
- Peripheral Blood BRCA1 Methylation Positively Correlates with Major Alzheimer's Disease Risk Factors.The journal of prevention of Alzheimer's disease · 2021Article
- Cohort-Specific Optimization of Models Predicting Preclinical Alzheimer's Disease, to Enhance Screening Performance in the Middle of Preclinical Alzheimer's Disease Clinical Studies.The journal of prevention of Alzheimer's disease · 2021Article
- Relation of Poor Nutritional Status to Mild Cognitive Impairment in Patients with Coronary Artery Disease.The journal of nutrition, health & aging · 2020Article
- Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area.International journal of environmental research and public health · 2019Article
- Visualizing modules of coordinated structural brain atrophy during the course of conversion to Alzheimer's disease by applying methodology from gene co-expression analysis.NeuroImage. Clinical · 2019Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
introductionThe objective of this study was to determine whether sex or education level affects the longitudinal rate of cognitive decline in Japanese patients in the Alzheimer's disease Neuroimaging Initiative study with defined mild cognitive impairment (MCI).
methodsWe accessed the entire Japanese Alzheimer's Disease Neuroimaging Initiative data set of 537 individuals, among whom 234 had MCI and 149 had Alzheimer's disease. We classified participants into three categories of educational history: (1) low, 0 to 9 years; (2) moderate, 10 to 15 years; and (3) high ≥16 years. We examined the main effects and interactions of visit, sex, and educational achievement on scores for the Clinical Dementia Rating Sum of Boxes, Alzheimer's Disease Assessment Scale-cognitive subscale 13, Mini-Mental State Examination, and Functional Activities Questionnaire in a longitudinal manner.
resultsWomen with MCI had a significantly faster rate of decline than men over a 3-year period. Highly educated men showed a significantly slower rate of decline than the other groups. Sex differences in the rates of decline remained after stratification by amyloid or apolipoprotein E ( DISCUSSION: In patients with MCI, sex and educational history significantly affected the rate of change in cognitive and clinical assessments. Furthermore, a subtle decline in chronic kidney disease grade was associated with a faster rate of decline regardless of amyloid pathology in women.
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